Product Information
SINEMET 25-100 MG TABLET is a brand product labeled by Organon LLC, priced at $1.4236 per EA under NDC 78206019001. Its NADAC has been published 68 times since May 7, 2025.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the carbidopa and levodopa market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25; 100 mg/1; mg/1
Manufacturer
Organon LLCNDC
78206019001
Classification
Brand
Dosage Form
TABLET
Route
ORAL
Effective Date
1/1/2026
Active Ingredients
CARBIDOPA; LEVODOPAApproval Type
New Drug (NDA)
FDA Application
NDA017555FDA Approved
Before 1982
TE Code
AB
On Market Since
2/28/2025
Pharmacological Classes
Price Statistics
The NADAC for SINEMET 25-100 MG TABLET has been published 68 times since May 7, 2025, and over the history we have for it it has risen 5.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.4236 per EA |
|---|---|
| All-time high | $1.4236 (Aug 19, 2026) |
| All-time low | $1.3558 (Dec 17, 2025) |
| 52-week high | $1.4236 |
| 52-week low | $1.3558 |
| Median price | $1.3570 |
| Average price | $1.3889 |
| Largest weekly change | +5.0% (Jan 7, 2026) |
| Weeks tracked | 68 |
| Tracking since | May 7, 2025 |
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 95% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of SINEMET 25-100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for SINEMET 25-100 MG TABLET, manufactured by Organon LLC, is $1.4236 per EA (NDC 78206019001), effective Aug 19, 2026.
How has the price of SINEMET 25-100 MG TABLET changed over time?
Over the history we have for it, the NADAC for SINEMET 25-100 MG TABLET has risen 5.0%. It has been tracked across 68 weekly CMS publications since May 7, 2025.
What are the highest and lowest recorded NADAC prices for SINEMET 25-100 MG TABLET?
Since May 7, 2025, the NADAC for SINEMET 25-100 MG TABLET has ranged from a low of $1.3558 (Dec 17, 2025) to a high of $1.4236 (Aug 19, 2026), with a median of $1.3570 per EA.
Are there cheaper alternatives to SINEMET 25-100 MG TABLET?
Yes. 6 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CARBIDOPA-LEVODOPA 25-100 TAB, is $0.0724 per EA — about 95% below SINEMET 25-100 MG TABLET.
Who manufactures SINEMET 25-100 MG TABLET?
SINEMET 25-100 MG TABLET (NDC 78206019001) is labeled by Organon LLC, and CMS classifies it as a brand product.