Leflunomide
23 NDCs across 11 manufacturers|22 Generic,1 Brand
Leflunomide is used to treat rheumatoid arthritis, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on Sep 10, 1998, and the first generic was approved Sep 13, 2005. FDA's Orange Book lists 20 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $36 million on Leflunomide across 579,000 claims for 148,000 beneficiaries.
Leflunomide is available as 23 NDCs from 11 manufacturers (22 generic, 1 brand), with NADAC prices from $0.29 to $37.84 per EA — the most expensive product costs about 129× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
23
22G / 1B
Manufacturers
11
competing in market
Price Spread
$0.29 – $37.84
per EA
7d Activity
avg +0.3% WoW · of 23 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Apotex Corp. manufacturer profile
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Lead class
Antirheumatic Agent class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
11 manufacturers producing LEFLUNOMIDE(2 pricing outliers)
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
ARAVA 20 MG TABLET | $37.8444 per EA | — |
LEFLUNOMIDE 10 MG TABLET | $0.3884 per EA | — |
LEFLUNOMIDE 20 MG TABLET | $0.3658 per EA | — |
LEFLUNOMIDE 20 MG TABLET | $0.3368 per EA | — |
LEFLUNOMIDE 10 MG TABLET | $0.3270 per EA | — |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 10 MG TABLET | $0.3237 per EA | -0.33% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
LEFLUNOMIDE 20 MG TABLET | $0.2944 per EA | +0.92% |
Frequently Asked Questions
What is Leflunomide used to treat?
Leflunomide is used to treat rheumatoid arthritis, per the National Library of Medicine's MED-RT classification.
When did Leflunomide become available as a generic?
FDA approved the first generic Leflunomide (ANDA) on Sep 13, 2005. The Orange Book currently lists 20 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Leflunomide?
In 2024, Medicare Part D spent $36 million on Leflunomide across 579,000 claims for 148,000 beneficiaries.
How many Leflunomide products are on the market?
The Leflunomide drug market contains 23 NDCs from 11 manufacturers — 22 generic and 1 brand product.
What is the price range for Leflunomide?
NADAC reference prices for Leflunomide range from $0.2944 to $37.8444 per EA — the most expensive product costs about 129× the cheapest.
Is generic Leflunomide cheaper than brand?
The average generic NADAC for Leflunomide is $0.3173 per EA, versus $37.8444 for brand-labeled products — brand versions average about 119× the generic price.
Which manufacturers make Leflunomide?
11 manufacturers list Leflunomide in NADAC. Ranked by number of NDCs, the largest are Apotex Corp. (4), KVK-Tech Inc. (2), Chartwell RX LLC (2), Heritage Pharmaceuticals Inc. (2), Burel Pharmaceuticals, LLC (2).
How has the price of Leflunomide changed recently?
Over the past 7 days, 9 Leflunomide NDCs rose and 9 fell, with a market-wide average change of +0.3%.