Morphine Sulfate

95 NDCs across 14 manufacturers|92 Generic,3 Brand

Morphine Sulfate is used to treat dyspnea and intractable pain, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved on Sep 18, 1984, and the first generic was approved Oct 7, 1986. FDA's Orange Book lists 34 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $76 million on Morphine Sulfate across 2.6 million claims for 488,000 beneficiaries.

Morphine Sulfate is available as 95 NDCs from 14 manufacturers (92 generic, 3 brand), with NADAC prices from $0.19 to $15.68 per EA — the most expensive product costs about 82× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Active FDA drug shortage

24 Morphine Sulfate presentations are currently listed in FDA's drug shortage database (first posted Oct 31, 2017). Shortages can move NADAC prices in the following weeks.

Total NDCs

92G / 3B

Manufacturers

competing in market

Price Spread

$0.19 – $15.68

per EA, 72 of 95 NDCs

7d Activity

23↑37↓35 flat

avg -0.9% WoW · of 95 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

14 manufacturers producing MORPHINE SULFATE

Hikma Pharmaceuticals USA Inc.

13 NDCs

$0.5660

avg/unit

Upsher-Smith Laboratories LLC

12 NDCs

$4.1283

avg/unit

Rhodes Pharmaceuticals L.P.

8 NDCs

$3.8531

avg/unit

Winder Laboratories LLC

Amneal Pharmaceuticals of New York LLC

6 NDCs

$5.5992

avg/unit

Lupin Pharmaceuticals Inc.

5 NDCs

$0.9370

avg/unit

Sun Pharmaceutical Industries Inc.

5 NDCs

$0.8481

avg/unit

Major Pharmaceuticals

4 NDCs

$0.5665

avg/unit

American Health Packaging

Cranbury Pharmaceuticals, LLC

2 NDCs

$0.3639

avg/unit

Ascend Laboratories, LLC

2 NDCs

$0.2931

avg/unit

Drug Portfolio

95 NDCs total, 95 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
MORPHINE SULFATE ER 120 MG CAP	00228309311	Actavis Pharma, Inc.	$15.6837 per EA	High Outlier	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 90 MG CAP	00228309211	Actavis Pharma, Inc.	$13.9076 per EA	High Outlier	Generic	—	Opioid Agonist
MS CONTIN 60 MG TABLET	42858076001	Rhodes Pharmaceuticals L.P.	$13.0046 per EA	—	Brand	—	Opioid Agonist
MORPHINE SULFATE ER 100 MG CAP	00115128201	Amneal Pharmaceuticals of New York LLC	$12.6512 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 80 MG CAP	00115128101	Amneal Pharmaceuticals of New York LLC	$10.0720 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 80 MG CAP	00832023050	Upsher-Smith Laboratories LLC	$9.7278 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 60 MG CAP	00228309111	Actavis Pharma, Inc.	$8.9771 per EA	High Outlier	Generic	—	Opioid Agonist
MS CONTIN ER 30 MG TABLET	42858063101	Rhodes Pharmaceuticals L.P.	$8.8990 per EA	—	Brand	—	Opioid Agonist
MORPHINE SULFATE ER 45 MG CAP	00228311611	Actavis Pharma, Inc.	$6.9631 per EA	High Outlier	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 100 MG CAP	00832023300	Upsher-Smith Laboratories LLC	$6.6922 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 50 MG CAP	00832022850	Upsher-Smith Laboratories LLC	$6.6583 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 60 MG CAP	00832022900	Upsher-Smith Laboratories LLC	$4.9757 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 80 MG CAP	00832023000	Upsher-Smith Laboratories LLC	$4.7853 per EA	—	Generic	—	Opioid Agonist
MS CONTIN ER 15 MG TABLET	42858051501	Rhodes Pharmaceuticals L.P.	$4.6807 per EA	—	Brand	—	Opioid Agonist
MORPHINE SULFATE ER 30 MG CAP	00228309011	Actavis Pharma, Inc.	$4.5987 per EA	High Outlier	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 30 MG CAP	00832022750	Upsher-Smith Laboratories LLC	$3.7385 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 50 MG CAP	00832022800	Upsher-Smith Laboratories LLC	$3.4065 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 30 MG CAP	00115127801	Amneal Pharmaceuticals of New York LLC	$3.3842 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 30 MG CAP	00832022700	Upsher-Smith Laboratories LLC	$3.2824 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 20 MG CAP	00832022600	Upsher-Smith Laboratories LLC	$3.0808 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 60 MG CAP	00115128001	Amneal Pharmaceuticals of New York LLC	$3.0306 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 20 MG CAP	00115127701	Amneal Pharmaceuticals of New York LLC	$2.8800 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 10 MG CAP	00832022500	Upsher-Smith Laboratories LLC	$2.6055 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF ER 200 MG TABLET	43386054401	Lupin Pharmaceuticals Inc.	$2.5441 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULFATE 10 MG/ML VIAL	00641612725	Hikma Pharmaceuticals USA Inc.	$2.3422 per ML	—	Generic	+0.04%	Opioid Agonist
MORPHINE SULFATE 4 MG/ML VIAL	00641612525	Hikma Pharmaceuticals USA Inc.	$2.3133 per ML	—	Generic	+0.33%	Opioid Agonist
MORPHINE SULF ER 200 MG TABLET	00406832001	SpecGx LLC	$1.9746 per EA	—	Generic	-0.13%	Opioid Agonist
MORPHINE SULF ER 200 MG TABLET	42858080501	Rhodes Pharmaceuticals L.P.	$1.9746 per EA	—	Generic	-0.13%	Opioid Agonist
MORPHINE SULF ER 200 MG TABLET	63304045301	Sun Pharmaceutical Industries Inc.	$1.9746 per EA	—	Generic	-0.13%	Opioid Agonist
MORPHINE 2 MG/ML CARPUJECT	00409189001	Hospira Inc.	$1.8340 per ML	—	Generic	—	Opioid Agonist
MORPHINE 10 MG/ML CARPUJECT	00409189301	Hospira Inc.	$1.5952 per ML	—	Generic	—	Opioid Agonist
MORPHINE SULFATE ER 50 MG CAP	00115127901	Amneal Pharmaceuticals of New York LLC	$1.5770 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	43386054301	Lupin Pharmaceuticals Inc.	$1.0493 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	00904656061	Major Pharmaceuticals	$0.8480 per EA	—	Generic	+0.02%	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	00406839062	SpecGx LLC	$0.8480 per EA	—	Generic	+0.02%	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	00406839023	SpecGx LLC	$0.8480 per EA	—	Generic	+0.02%	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	00406839001	SpecGx LLC	$0.8480 per EA	—	Generic	+0.02%	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	63304045201	Sun Pharmaceutical Industries Inc.	$0.8480 per EA	—	Generic	+0.02%	Opioid Agonist
MORPHINE SULF ER 100 MG TABLET	42858080401	Rhodes Pharmaceuticals L.P.	$0.8480 per EA	—	Generic	+0.02%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	00904655961	Major Pharmaceuticals	$0.6496 per EA	—	Generic	+2.23%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	00406838001	SpecGx LLC	$0.6496 per EA	—	Generic	+2.23%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	00406838023	SpecGx LLC	$0.6496 per EA	—	Generic	+2.23%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	00406838062	SpecGx LLC	$0.6496 per EA	—	Generic	+2.23%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	42858080301	Rhodes Pharmaceuticals L.P.	$0.6496 per EA	—	Generic	+2.23%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	63304075801	Sun Pharmaceutical Industries Inc.	$0.6496 per EA	—	Generic	+2.23%	Opioid Agonist
MORPHINE SULF ER 60 MG TABLET	43386054201	Lupin Pharmaceuticals Inc.	$0.5543 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	75826013115	Winder Laboratories LLC	$0.4796 per ML	—	Generic	-1.27%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	00054051741	Hikma Pharmaceuticals USA Inc.	$0.4796 per ML	—	Generic	-1.27%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	00406800315	SpecGx LLC	$0.4796 per ML	—	Generic	-1.27%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	00406833062	SpecGx LLC	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	63304045101	Sun Pharmaceutical Industries Inc.	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	68084015801	American Health Packaging	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	00904655861	Major Pharmaceuticals	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	00406833023	SpecGx LLC	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	42858080201	Rhodes Pharmaceuticals L.P.	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	00406833001	SpecGx LLC	$0.4555 per EA	—	Generic	+5.10%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	00228427111	Actavis Pharma, Inc.	$0.4334 per EA	High Outlier	Generic	—	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	75826013101	Winder Laboratories LLC	$0.4096 per ML	—	Generic	-2.18%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	27808008201	Cranbury Pharmaceuticals, LLC	$0.4096 per ML	—	Generic	-2.18%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	00054051744	Hikma Pharmaceuticals USA Inc.	$0.4096 per ML	—	Generic	-2.18%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	00406800330	SpecGx LLC	$0.4096 per ML	—	Generic	-2.18%	Opioid Agonist
MORPHINE SULFATE IR 30 MG TAB	67877067101	Ascend Laboratories, LLC	$0.3580 per EA	—	Generic	-9.13%	Opioid Agonist
MORPHINE SULFATE IR 30 MG TAB	00406511901	SpecGx LLC	$0.3580 per EA	—	Generic	-9.13%	Opioid Agonist
MORPHINE SULFATE IR 30 MG TAB	00406511962	SpecGx LLC	$0.3580 per EA	—	Generic	-9.13%	Opioid Agonist
MORPHINE SULFATE IR 30 MG TAB	00054023624	Hikma Pharmaceuticals USA Inc.	$0.3580 per EA	—	Generic	-9.13%	Opioid Agonist
MORPHINE SULFATE IR 30 MG TAB	00054023625	Hikma Pharmaceuticals USA Inc.	$0.3580 per EA	—	Generic	-9.13%	Opioid Agonist
MORPHINE SULFATE IR 30 MG TAB	00832027411	Upsher-Smith Laboratories LLC	$0.3580 per EA	—	Generic	-9.13%	Opioid Agonist
MORPHINE SULF ER 30 MG TABLET	43386054101	Lupin Pharmaceuticals Inc.	$0.3462 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	27808008202	Cranbury Pharmaceuticals, LLC	$0.3182 per ML	—	Generic	-1.40%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	00054051750	Hikma Pharmaceuticals USA Inc.	$0.3182 per ML	—	Generic	-1.40%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	75826013104	Winder Laboratories LLC	$0.3182 per ML	—	Generic	-1.40%	Opioid Agonist
MORPHINE SULF 100 MG/5 ML CONC	00406800312	SpecGx LLC	$0.3182 per ML	—	Generic	-1.40%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	00406831562	SpecGx LLC	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	42858080101	Rhodes Pharmaceuticals L.P.	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	68084015701	American Health Packaging	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	00904655761	Major Pharmaceuticals	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	63304045001	Sun Pharmaceutical Industries Inc.	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	00406831523	SpecGx LLC	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	00406831501	SpecGx LLC	$0.3130 per EA	—	Generic	-1.63%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	00054023525	Hikma Pharmaceuticals USA Inc.	$0.2282 per EA	—	Generic	-3.44%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	67877067001	Ascend Laboratories, LLC	$0.2282 per EA	—	Generic	-3.44%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	00406511862	SpecGx LLC	$0.2282 per EA	—	Generic	-3.44%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	00406511801	SpecGx LLC	$0.2282 per EA	—	Generic	-3.44%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	00832027311	Upsher-Smith Laboratories LLC	$0.2282 per EA	—	Generic	-3.44%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	00054023524	Hikma Pharmaceuticals USA Inc.	$0.2282 per EA	—	Generic	-3.44%	Opioid Agonist
MORPHINE SULFATE IR 15 MG TAB	60687061701	American Health Packaging	$0.2135 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF ER 15 MG TABLET	43386054001	Lupin Pharmaceuticals Inc.	$0.1910 per EA	—	Generic	—	Opioid Agonist
MORPHINE SULF 20 MG/5 ML SOLN	00054023849	Hikma Pharmaceuticals USA Inc.	$0.1201 per ML	—	Generic	-0.03%	Opioid Agonist
MORPHINE SULF 20 MG/5 ML SOLN	75826013005	Winder Laboratories LLC	$0.1201 per ML	—	Generic	-0.03%	Opioid Agonist
MORPHINE SULF 10 MG/5 ML SOLN	00054023749	Hikma Pharmaceuticals USA Inc.	$0.0907 per ML	—	Generic	+1.43%	Opioid Agonist
MORPHINE SULF 10 MG/5 ML SOLN	75826012905	Winder Laboratories LLC	$0.0907 per ML	—	Generic	+1.43%	Opioid Agonist
MORPHINE SULF 20 MG/5 ML SOLN	00054023863	Hikma Pharmaceuticals USA Inc.	$0.0682 per ML	—	Generic	—	Opioid Agonist
MORPHINE SULF 20 MG/5 ML SOLN	75826013017	Winder Laboratories LLC	$0.0682 per ML	—	Generic	—	Opioid Agonist
MORPHINE SULF 10 MG/5 ML SOLN	75826012917	Winder Laboratories LLC	$0.0438 per ML	—	Generic	-1.55%	Opioid Agonist
MORPHINE SULF 10 MG/5 ML SOLN	00054023763	Hikma Pharmaceuticals USA Inc.	$0.0438 per ML	—	Generic	-1.55%	Opioid Agonist

Frequently Asked Questions

What is Morphine Sulfate used to treat?

Morphine Sulfate is used to treat dyspnea and intractable pain, per the National Library of Medicine's MED-RT classification.

When did Morphine Sulfate become available as a generic?

FDA approved the first generic Morphine Sulfate (ANDA) on Oct 7, 1986. The Orange Book currently lists 34 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Morphine Sulfate?

In 2024, Medicare Part D spent $76 million on Morphine Sulfate across 2.6 million claims for 488,000 beneficiaries.

Is Morphine Sulfate in shortage?

Yes — FDA's drug shortage database currently lists 24 Morphine Sulfate presentations with status "Current", first posted Oct 31, 2017.

How many Morphine Sulfate products are on the market?

The Morphine Sulfate drug market contains 95 NDCs from 14 manufacturers — 92 generic and 3 brand products.

What is the price range for Morphine Sulfate?

NADAC reference prices for Morphine Sulfate range from $0.1910 to $15.6837 per EA — the most expensive product costs about 82× the cheapest. 23 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Is generic Morphine Sulfate cheaper than brand?

The average generic NADAC for Morphine Sulfate is $2.3452 per EA, versus $8.8614 for brand-labeled products — brand versions average about 3.8× the generic price.

Which manufacturers make Morphine Sulfate?

14 manufacturers list Morphine Sulfate in NADAC. Ranked by number of NDCs, the largest are SpecGx LLC (20), Hikma Pharmaceuticals USA Inc. (13), Upsher-Smith Laboratories LLC (12), Rhodes Pharmaceuticals L.P. (8), Winder Laboratories LLC (7).

How has the price of Morphine Sulfate changed recently?

Over the past 7 days, 23 Morphine Sulfate NDCs rose and 37 fell, with a market-wide average change of -0.9%.