Progesterone

24 NDCs across 13 manufacturers|19 Generic,5 Brand

Progesterone is used to treat amenorrhea, endometrial hyperplasia, female infertility and uterine hemorrhage, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved before 1982, and the first generic was approved Apr 25, 2001. FDA's Orange Book lists 17 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $8K on Progesterone across 216 claims for 100 beneficiaries.

Progesterone is available as 24 NDCs from 13 manufacturers (19 generic, 5 brand), with NADAC prices from $0.23 to $30.42 per EA — the most expensive product costs about 132× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

19G / 5B

Manufacturers

competing in market

Price Spread

$0.23 – $30.42

per EA, 17 of 24 NDCs

7d Activity

7↑12↓5 flat

avg -0.9% WoW · of 24 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

13 manufacturers producing PROGESTERONE(3 pricing outliers)

Acertis Pharmaceuticals, LLC

Dr. Reddy's Laboratories Inc.

Amneal Pharmaceuticals LLC

2 NDCs

$0.3241

avg/unit

Aurobindo Pharma Limited

2 NDCs

$0.3241

avg/unit

Ferring Pharmaceuticals Inc.

Hikma Pharmaceuticals USA Inc.

Fresenius Kabi USA, LLC

Drug Portfolio

24 NDCs total, 24 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
PROMETRIUM 200 MG CAPSULE	72989037330	Acertis Pharmaceuticals, LLC	$30.4165 per EA	High Outlier	Brand	+0.02%	Progesterone
CRINONE 8% GEL	00023615108	Allergan, Inc.	$27.9820 per GM	High Outlier	Brand	-0.14%	Progesterone
CRINONE 4% GEL	00023615004	Allergan, Inc.	$16.8439 per GM	High Outlier	Brand	—	Progesterone
PROMETRIUM 100 MG CAPSULE	72989037230	Acertis Pharmaceuticals, LLC	$15.9205 per EA	High Outlier	Brand	-0.13%	Progesterone
ENDOMETRIN 100 MG VAG INSERT	55566650003	Ferring Pharmaceuticals Inc.	$15.1518 per EA	High Outlier	Brand	—	Progesterone
PROGESTERONE 500 MG/10 ML VIAL	00143972501	Hikma Pharmaceuticals USA Inc.	$1.4354 per ML	—	Generic	-3.29%	Progesterone
PROGESTERONE 500 MG/10 ML VIAL	00591312879	Actavis Pharma, Inc.	$1.4354 per ML	—	Generic	-3.29%	Progesterone
PROGESTERONE 500 MG/10 ML VIAL	63323026110	Fresenius Kabi USA, LLC	$1.4354 per ML	—	Generic	-3.29%	Progesterone
PROGESTERONE 500 MG/10 ML VIAL	55150030610	Eugia US LLC	$1.4354 per ML	—	Generic	-3.29%	Progesterone
PROGESTERONE 500 MG/10 ML VIAL	70700028622	Xiromed LLC	$1.4354 per ML	—	Generic	-3.29%	Progesterone
PROGESTERONE 200 MG CAPSULE	69452014920	Bionpharma Inc.	$0.4791 per EA	—	Generic	—	Progesterone
PROGESTERONE 200 MG CAPSULE	43598035001	Dr. Reddy's Laboratories Inc.	$0.4249 per EA	—	Generic	—	Progesterone
PROGESTERONE 200 MG CAPSULE	16714015801	NorthStar Rx LLC	$0.4170 per EA	—	Generic	-2.11%	Progesterone
PROGESTERONE 200 MG CAPSULE	65162080810	Amneal Pharmaceuticals LLC	$0.4170 per EA	—	Generic	-2.11%	Progesterone
PROGESTERONE 200 MG CAPSULE	59651015301	Aurobindo Pharma Limited	$0.4170 per EA	—	Generic	-2.11%	Progesterone
PROGESTERONE 200 MG CAPSULE	69452023420	Bionpharma Inc.	$0.4170 per EA	—	Generic	-2.11%	Progesterone
PROGESTERONE 200 MG CAPSULE	70700016301	Xiromed LLC	$0.4170 per EA	—	Generic	-2.11%	Progesterone
PROGESTERONE 100 MG CAPSULE	69452014820	Bionpharma Inc.	$0.2578 per EA	—	Generic	—	Progesterone
PROGESTERONE 100 MG CAPSULE	70700016201	Xiromed LLC	$0.2312 per EA	—	Generic	+1.71%	Progesterone
PROGESTERONE 100 MG CAPSULE	59651015201	Aurobindo Pharma Limited	$0.2312 per EA	—	Generic	+1.71%	Progesterone
PROGESTERONE 100 MG CAPSULE	65162080710	Amneal Pharmaceuticals LLC	$0.2312 per EA	—	Generic	+1.71%	Progesterone
PROGESTERONE 100 MG CAPSULE	69452023320	Bionpharma Inc.	$0.2312 per EA	—	Generic	+1.71%	Progesterone
PROGESTERONE 100 MG CAPSULE	43598034901	Dr. Reddy's Laboratories Inc.	$0.2312 per EA	—	Generic	+1.71%	Progesterone
PROGESTERONE 100 MG CAPSULE	16714015701	NorthStar Rx LLC	$0.2312 per EA	—	Generic	+1.71%	Progesterone

Frequently Asked Questions

What is Progesterone used to treat?

Progesterone is used to treat amenorrhea, endometrial hyperplasia, female infertility and uterine hemorrhage, per the National Library of Medicine's MED-RT classification.

When did Progesterone become available as a generic?

FDA approved the first generic Progesterone (ANDA) on Apr 25, 2001. The Orange Book currently lists 17 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Progesterone?

In 2024, Medicare Part D spent $8K on Progesterone across 216 claims for 100 beneficiaries.

How many Progesterone products are on the market?

The Progesterone drug market contains 24 NDCs from 13 manufacturers — 19 generic and 5 brand products.

What is the price range for Progesterone?

NADAC reference prices for Progesterone range from $0.2312 to $30.4165 per EA — the most expensive product costs about 132× the cheapest. 7 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Is generic Progesterone cheaper than brand?

The average generic NADAC for Progesterone is $0.3310 per EA, versus $20.4963 for brand-labeled products — brand versions average about 62× the generic price.

Which manufacturers make Progesterone?

13 manufacturers list Progesterone in NADAC. Ranked by number of NDCs, the largest are Bionpharma Inc. (4), Xiromed LLC (3), Acertis Pharmaceuticals, LLC (2), Allergan, Inc. (2), Dr. Reddy's Laboratories Inc. (2).

How has the price of Progesterone changed recently?

Over the past 7 days, 7 Progesterone NDCs rose and 12 fell, with a market-wide average change of -0.9%.