Product Information
LEUCOVORIN CALCIUM 25 MG TAB is a generic product labeled by Hikma Pharmaceuticals USA Inc., priced at $1.6047 per EA under NDC 00054449911. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Feb 22, 1993. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Hikma Pharmaceuticals USA Inc.NDC
00054449911
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
LEUCOVORIN CALCIUMApproval Type
Generic (ANDA)
FDA Application
ANDA072736FDA Approved
2/22/1993
TE Code
AB
On Market Since
2/22/1993
Pharmacological Classes
Price Statistics
The NADAC for LEUCOVORIN CALCIUM 25 MG TAB has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 77.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.6047 per EA |
|---|---|
| All-time high | $8.3398 (Jun 11, 2014) |
| All-time low | $1.5005 (Dec 20, 2023) |
| 52-week high | $3.3199 |
| 52-week low | $1.6047 |
| Median price | $5.7390 |
| Average price | $5.3485 |
| Largest weekly change | -65.9% (Dec 20, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Hikma Pharmaceuticals USA Inc. manufacturer profile
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Drug market
Leucovorin Calcium market comparison
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Therapeutic class
Folate Analog class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LEUCOVORIN CALCIUM 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for LEUCOVORIN CALCIUM 25 MG TAB, manufactured by Hikma Pharmaceuticals USA Inc., is $1.6047 per EA (NDC 00054449911), effective Sep 30, 2026.
How has the price of LEUCOVORIN CALCIUM 25 MG TAB changed over time?
Over the history we have for it, the NADAC for LEUCOVORIN CALCIUM 25 MG TAB has declined 77.1%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for LEUCOVORIN CALCIUM 25 MG TAB?
Since Nov 28, 2013, the NADAC for LEUCOVORIN CALCIUM 25 MG TAB has ranged from a low of $1.5005 (Dec 20, 2023) to a high of $8.3398 (Jun 11, 2014), with a median of $5.7390 per EA.
Are there cheaper alternatives to LEUCOVORIN CALCIUM 25 MG TAB?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LEUCOVORIN CALCIUM 25 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures LEUCOVORIN CALCIUM 25 MG TAB?
LEUCOVORIN CALCIUM 25 MG TAB (NDC 00054449911) is labeled by Hikma Pharmaceuticals USA Inc., and CMS classifies it as a generic product.