Product Information
LEUCOVORIN CALCIUM 25 MG TAB is a generic product labeled by Epic Pharma LLC, priced at $1.6047 per EA under NDC 42806035925. Its NADAC has been published 312 times since Oct 14, 2020.
FDA first approved this application on Aug 28, 1997. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Epic Pharma LLCNDC
42806035925
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
LEUCOVORIN CALCIUMApproval Type
Generic (ANDA)
FDA Application
ANDA074544FDA Approved
8/28/1997
TE Code
AB
On Market Since
4/16/2020
Pharmacological Classes
Price Statistics
The NADAC for LEUCOVORIN CALCIUM 25 MG TAB has been published 312 times since Oct 14, 2020, and over the history we have for it it has declined 75.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.6047 per EA |
|---|---|
| All-time high | $6.6745 (May 12, 2021) |
| All-time low | $1.5005 (Dec 20, 2023) |
| 52-week high | $3.3199 |
| 52-week low | $1.6047 |
| Median price | $4.1702 |
| Average price | $4.0944 |
| Largest weekly change | -65.9% (Dec 20, 2023) |
| Weeks tracked | 312 |
| Tracking since | Oct 14, 2020 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Epic Pharma LLC manufacturer profile
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Drug market
Leucovorin Calcium market comparison
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Therapeutic class
Folate Analog class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LEUCOVORIN CALCIUM 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for LEUCOVORIN CALCIUM 25 MG TAB, manufactured by Epic Pharma LLC, is $1.6047 per EA (NDC 42806035925), effective Sep 30, 2026.
How has the price of LEUCOVORIN CALCIUM 25 MG TAB changed over time?
Over the history we have for it, the NADAC for LEUCOVORIN CALCIUM 25 MG TAB has declined 75.1%. It has been tracked across 312 weekly CMS publications since Oct 14, 2020.
What are the highest and lowest recorded NADAC prices for LEUCOVORIN CALCIUM 25 MG TAB?
Since Oct 14, 2020, the NADAC for LEUCOVORIN CALCIUM 25 MG TAB has ranged from a low of $1.5005 (Dec 20, 2023) to a high of $6.6745 (May 12, 2021), with a median of $4.1702 per EA.
Are there cheaper alternatives to LEUCOVORIN CALCIUM 25 MG TAB?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LEUCOVORIN CALCIUM 25 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures LEUCOVORIN CALCIUM 25 MG TAB?
LEUCOVORIN CALCIUM 25 MG TAB (NDC 42806035925) is labeled by Epic Pharma LLC, and CMS classifies it as a generic product.