Product Information
LEUCOVORIN CALCIUM 25 MG TAB is a generic product labeled by Major Pharmaceuticals, priced at $1.9779 per EA under NDC 00904670310. Its NADAC has been published 383 times since Jan 23, 2019.
FDA first approved this application on Feb 22, 1993. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
The High Outlier badge above means this manufacturer's average price in the Leucovorin Calcium market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
25 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904670310
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
5/20/2026
Active Ingredients
LEUCOVORIN CALCIUMApproval Type
Generic (ANDA)
FDA Application
ANDA072736FDA Approved
2/22/1993
TE Code
AB
On Market Since
2/22/1993
Pharmacological Classes
Price Statistics
The NADAC for LEUCOVORIN CALCIUM 25 MG TAB has been published 383 times since Jan 23, 2019, and over the history we have for it it has declined 65.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.9779 per EA |
|---|---|
| All-time high | $6.9349 (Aug 14, 2019) |
| All-time low | $1.5005 (Dec 20, 2023) |
| 52-week high | $3.3199 |
| 52-week low | $1.9779 |
| Median price | $5.0042 |
| Average price | $4.6571 |
| Largest weekly change | -65.9% (Dec 20, 2023) |
| Weeks tracked | 383 |
| Tracking since | Jan 23, 2019 |
1W
N/A
1M
N/A
3M
N/A
6M
-16.1%
1Y
-2.6%
3Y
-52.6%
5Y
-62.6%
All
-65.1%
Last surveyed May 20, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 19% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Major Pharmaceuticals manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Leucovorin Calcium market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Folate Analog class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LEUCOVORIN CALCIUM 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for LEUCOVORIN CALCIUM 25 MG TAB, manufactured by Major Pharmaceuticals, is $1.9779 per EA (NDC 00904670310), effective May 20, 2026.
How has the price of LEUCOVORIN CALCIUM 25 MG TAB changed over time?
Over the history we have for it, the NADAC for LEUCOVORIN CALCIUM 25 MG TAB has declined 65.1%. It has been tracked across 383 weekly CMS publications since Jan 23, 2019.
What are the highest and lowest recorded NADAC prices for LEUCOVORIN CALCIUM 25 MG TAB?
Since Jan 23, 2019, the NADAC for LEUCOVORIN CALCIUM 25 MG TAB has ranged from a low of $1.5005 (Dec 20, 2023) to a high of $6.9349 (Aug 14, 2019), with a median of $5.0042 per EA.
Are there cheaper alternatives to LEUCOVORIN CALCIUM 25 MG TAB?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, LEUCOVORIN CALCIUM 25 MG TAB, is $1.6047 per EA — about 19% below LEUCOVORIN CALCIUM 25 MG TAB.
Who manufactures LEUCOVORIN CALCIUM 25 MG TAB?
LEUCOVORIN CALCIUM 25 MG TAB (NDC 00904670310) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.