Product Information
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM is a generic product labeled by PAI Holdings LLC, priced at $0.2211 per GM under NDC 00121100230. Its NADAC has been published 63 times since Jun 11, 2025.
FDA first approved this application on Jun 29, 2018.
Strength
25; 25 mg/g; mg/g
Manufacturer
PAI Holdings LLCNDC
00121100230
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
LIDOCAINE; PRILOCAINEApproval Type
Generic (ANDA)
FDA Application
ANDA205887FDA Approved
6/29/2018
On Market Since
2/6/2025
Pharmacological Classes
Price Statistics
The NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has been published 63 times since Jun 11, 2025, and over the history we have for it it has declined 20.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2211 per GM |
|---|---|
| All-time high | $0.2791 (Jun 11, 2025) |
| All-time low | $0.2164 (Jun 17, 2026) |
| 52-week high | $0.2733 |
| 52-week low | $0.2164 |
| Median price | $0.2694 |
| Average price | $0.2532 |
| Largest weekly change | -6.4% (Mar 18, 2026) |
| Weeks tracked | 63 |
| Tracking since | Jun 11, 2025 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM, manufactured by PAI Holdings LLC, is $0.2211 per GM (NDC 00121100230), effective Aug 19, 2026.
How has the price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM changed over time?
Over the history we have for it, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has declined 20.8%. It has been tracked across 63 weekly CMS publications since Jun 11, 2025.
What are the highest and lowest recorded NADAC prices for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
Since Jun 11, 2025, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has ranged from a low of $0.2164 (Jun 17, 2026) to a high of $0.2791 (Jun 11, 2025), with a median of $0.2694 per GM.
Are there cheaper alternatives to LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM (NDC 00121100230) is labeled by PAI Holdings LLC, and CMS classifies it as a generic product.