Product Information
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM is a generic product labeled by Padagis US LLC, priced at $0.2317 per GM under NDC 00574204230. Its NADAC has been published 191 times since Feb 8, 2023.
FDA first approved this application on Jul 27, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25; 25 mg/g; mg/g
Manufacturer
Padagis US LLCNDC
00574204230
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
LIDOCAINE; PRILOCAINEApproval Type
Generic (ANDA)
FDA Application
ANDA212482FDA Approved
7/27/2021
TE Code
AB
On Market Since
12/20/2022
Pharmacological Classes
Price Statistics
The NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has been published 191 times since Feb 8, 2023, and over the history we have for it it has declined 51.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2317 per GM |
|---|---|
| All-time high | $0.6001 (Oct 11, 2023) |
| All-time low | $0.2164 (Jun 17, 2026) |
| 52-week high | $0.2733 |
| 52-week low | $0.2164 |
| Median price | $0.2863 |
| Average price | $0.3160 |
| Largest weekly change | -37.1% (Oct 18, 2023) |
| Weeks tracked | 191 |
| Tracking since | Feb 8, 2023 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 5% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis US LLC manufacturer profile
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Drug market
Lidocaine and Prilocaine market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Amide Local Anesthetic class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM, manufactured by Padagis US LLC, is $0.2317 per GM (NDC 00574204230), effective Sep 30, 2026.
How has the price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM changed over time?
Over the history we have for it, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has declined 51.4%. It has been tracked across 191 weekly CMS publications since Feb 8, 2023.
What are the highest and lowest recorded NADAC prices for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
Since Feb 8, 2023, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has ranged from a low of $0.2164 (Jun 17, 2026) to a high of $0.6001 (Oct 11, 2023), with a median of $0.2863 per GM.
Are there cheaper alternatives to LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM, is $0.2211 per GM — about 5% below LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM.
Who manufactures LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM (NDC 00574204230) is labeled by Padagis US LLC, and CMS classifies it as a generic product.