Product Information
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM is a generic product labeled by Padagis US LLC, priced at $0.2211 per GM under NDC 00574204230. Its NADAC has been published 185 times since Feb 8, 2023.
FDA first approved this application on Jul 27, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25; 25 mg/g; mg/g
Manufacturer
Padagis US LLCNDC
00574204230
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
LIDOCAINE; PRILOCAINEApproval Type
Generic (ANDA)
FDA Application
ANDA212482FDA Approved
7/27/2021
TE Code
AB
On Market Since
12/20/2022
Pharmacological Classes
Price Statistics
The NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has been published 185 times since Feb 8, 2023, and over the history we have for it it has declined 53.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2211 per GM |
|---|---|
| All-time high | $0.6001 (Oct 11, 2023) |
| All-time low | $0.2164 (Jun 17, 2026) |
| 52-week high | $0.2733 |
| 52-week low | $0.2164 |
| Median price | $0.2908 |
| Average price | $0.3190 |
| Largest weekly change | -37.1% (Oct 18, 2023) |
| Weeks tracked | 185 |
| Tracking since | Feb 8, 2023 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM, manufactured by Padagis US LLC, is $0.2211 per GM (NDC 00574204230), effective Aug 19, 2026.
How has the price of LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM changed over time?
Over the history we have for it, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has declined 53.6%. It has been tracked across 185 weekly CMS publications since Feb 8, 2023.
What are the highest and lowest recorded NADAC prices for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
Since Feb 8, 2023, the NADAC for LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM has ranged from a low of $0.2164 (Jun 17, 2026) to a high of $0.6001 (Oct 11, 2023), with a median of $0.2908 per GM.
Are there cheaper alternatives to LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM?
LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM (NDC 00574204230) is labeled by Padagis US LLC, and CMS classifies it as a generic product.