Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by PAI Holdings LLC, priced at $0.0383 per ML under NDC 00121107016. Its NADAC has been published 49 times since Jul 30, 2025.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
PAI Holdings LLCNDC
00121107016
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Last Updated
6/17/2026
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040649On Market Since
6/4/2025
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 49 times since Jul 30, 2025, and over the history we have for it it has declined 16.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0383 per ML |
|---|---|
| All-time high | $0.0457 (Aug 13, 2025) |
| All-time low | $0.0383 (Jun 17, 2026) |
| 52-week high | $0.0457 |
| 52-week low | $0.0383 |
| Median price | $0.0428 |
| Average price | $0.0418 |
| Largest weekly change | -4.3% (Feb 18, 2026) |
| Weeks tracked | 49 |
| Tracking since | Jul 30, 2025 |
Generic Alternatives
The matcher finds 5 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 5 manufacturers (up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by PAI Holdings LLC, is $0.0383 per ML (NDC 00121107016), effective Jul 1, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has declined 16.2%. It has been tracked across 49 weekly CMS publications since Jul 30, 2025.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since Jul 30, 2025, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0383 (Jun 17, 2026) to a high of $0.0457 (Aug 13, 2025), with a median of $0.0428 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
5 NADAC-published products share the same active ingredient, strength, and dosage form as PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, but none are currently priced below it.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 00121107016) is labeled by PAI Holdings LLC, and CMS classifies it as a generic product.
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