Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by PAI Holdings LLC, priced at $0.0390 per ML under NDC 00121107016. Its NADAC has been published 62 times since Jul 30, 2025.
FDA first approved this application on Feb 14, 2006. Its Orange Book therapeutic-equivalence code is AA.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
PAI Holdings LLCNDC
00121107016
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040649FDA Approved
2/14/2006
TE Code
AA
On Market Since
6/4/2025
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 62 times since Jul 30, 2025, and over the history we have for it it has declined 14.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0390 per ML |
|---|---|
| All-time high | $0.0457 (Aug 13, 2025) |
| All-time low | $0.0377 (Jul 22, 2026) |
| 52-week high | $0.0438 |
| 52-week low | $0.0377 |
| Median price | $0.0407 |
| Average price | $0.0411 |
| Largest weekly change | -4.3% (Feb 18, 2026) |
| Weeks tracked | 62 |
| Tracking since | Jul 30, 2025 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
PAI Holdings LLC manufacturer profile
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Drug market
Promethazine Hydrochloride and Dextromethorphan Hydrobromide market comparison
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Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by PAI Holdings LLC, is $0.0390 per ML (NDC 00121107016), effective Sep 30, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has declined 14.6%. It has been tracked across 62 weekly CMS publications since Jul 30, 2025.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since Jul 30, 2025, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0377 (Jul 22, 2026) to a high of $0.0457 (Aug 13, 2025), with a median of $0.0407 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 00121107016) is labeled by PAI Holdings LLC, and CMS classifies it as a generic product.