Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $0.0390 per ML under NDC 65162068090. Its NADAC has been published 335 times since May 6, 2020.
FDA first approved this application on Feb 8, 2011. Its Orange Book therapeutic-equivalence code is AA.
The High Outlier badge above means this manufacturer's average price in the Promethazine Hydrochloride and Dextromethorphan Hydrobromide market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162068090
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090575FDA Approved
2/8/2011
TE Code
AA
On Market Since
3/4/2011
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 335 times since May 6, 2020, and over the history we have for it it has declined 37.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0390 per ML |
|---|---|
| All-time high | $0.0669 (Dec 16, 2020) |
| All-time low | $0.0293 (Nov 20, 2024) |
| 52-week high | $0.0438 |
| 52-week low | $0.0377 |
| Median price | $0.0444 |
| Average price | $0.0493 |
| Largest weekly change | -29.1% (Nov 20, 2024) |
| Weeks tracked | 335 |
| Tracking since | May 6, 2020 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
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Drug market
Promethazine Hydrochloride and Dextromethorphan Hydrobromide market comparison
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Therapeutic class
Phenothiazine class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by Amneal Pharmaceuticals LLC, is $0.0390 per ML (NDC 65162068090), effective Sep 30, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has declined 37.8%. It has been tracked across 335 weekly CMS publications since May 6, 2020.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since May 6, 2020, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0293 (Nov 20, 2024) to a high of $0.0669 (Dec 16, 2020), with a median of $0.0444 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 65162068090) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.