Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by Cranbury Pharmaceuticals, LLC, priced at $0.0390 per ML under NDC 27808005701. Its NADAC has been published 240 times since Mar 2, 2022.
FDA first approved this application on Jun 28, 2012. Its Orange Book therapeutic-equivalence code is AA.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Cranbury Pharmaceuticals, LLCNDC
27808005701
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA091687FDA Approved
6/28/2012
TE Code
AA
On Market Since
1/31/2014
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 240 times since Mar 2, 2022, and over the history we have for it it has declined 29.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0390 per ML |
|---|---|
| All-time high | $0.0612 (May 11, 2022) |
| All-time low | $0.0293 (Nov 20, 2024) |
| 52-week high | $0.0438 |
| 52-week low | $0.0377 |
| Median price | $0.0434 |
| Average price | $0.0439 |
| Largest weekly change | -29.1% (Nov 20, 2024) |
| Weeks tracked | 240 |
| Tracking since | Mar 2, 2022 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Cranbury Pharmaceuticals, LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Promethazine Hydrochloride and Dextromethorphan Hydrobromide market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Phenothiazine class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by Cranbury Pharmaceuticals, LLC, is $0.0390 per ML (NDC 27808005701), effective Sep 30, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has declined 29.6%. It has been tracked across 240 weekly CMS publications since Mar 2, 2022.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since Mar 2, 2022, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0293 (Nov 20, 2024) to a high of $0.0612 (May 11, 2022), with a median of $0.0434 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION in a comparable dosage form, but none are currently priced below it.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 27808005701) is labeled by Cranbury Pharmaceuticals, LLC, and CMS classifies it as a generic product.