Product Information
ESTRADIOL 0.05 MG PATCH (1/WK) is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $10.8027 per EA under NDC 00378335099. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application on Feb 24, 2000. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.05 mg/d
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378335099
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA075182FDA Approved
2/24/2000
TE Code
AB2
On Market Since
3/1/2000
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has been published 665 times since Nov 28, 2013, and over the history we have for it it has declined 18.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $10.8027 per EA |
|---|---|
| All-time high | $17.1473 (Apr 16, 2014) |
| All-time low | $8.7935 (Jul 17, 2024) |
| 52-week high | $12.5223 |
| 52-week low | $10.6280 |
| Median price | $13.2581 |
| Average price | $13.3977 |
| Largest weekly change | +37.2% (Aug 21, 2024) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 24% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.05 MG PATCH (1/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.05 MG PATCH (1/WK), manufactured by Mylan Pharmaceuticals Inc., is $10.8027 per EA (NDC 00378335099), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.05 MG PATCH (1/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has declined 18.1%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.05 MG PATCH (1/WK)?
Since Nov 28, 2013, the NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has ranged from a low of $8.7935 (Jul 17, 2024) to a high of $17.1473 (Apr 16, 2014), with a median of $13.2581 per EA.
Are there cheaper alternatives to ESTRADIOL 0.05 MG PATCH (1/WK)?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ESTRADIOL 0.05 MG PATCH (2/WK), is $8.2223 per EA — about 24% below ESTRADIOL 0.05 MG PATCH (1/WK).
Who manufactures ESTRADIOL 0.05 MG PATCH (1/WK)?
ESTRADIOL 0.05 MG PATCH (1/WK) (NDC 00378335099) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.