Product Information
DIPHENHYDRAMINE 25 MG TABLET is a generic product labeled by Rugby Laboratories, priced at $0.0374 per EA under NDC 00536121429. Its NADAC has been published 371 times since Jul 17, 2019.
Strength
25 mg/1
Manufacturer
Rugby LaboratoriesNDC
00536121429
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M012On Market Since
3/28/2019
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 25 MG TABLET has been published 371 times since Jul 17, 2019, and over the history we have for it it has risen 8.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0374 per EA |
|---|---|
| All-time high | $0.0401 (Jul 12, 2023) |
| All-time low | $0.0299 (May 22, 2024) |
| 52-week high | $0.0384 |
| 52-week low | $0.0316 |
| Median price | $0.0355 |
| Average price | $0.0353 |
| Largest weekly change | -15.9% (May 22, 2024) |
| Weeks tracked | 371 |
| Tracking since | Jul 17, 2019 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 4% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 25 MG TABLET, manufactured by Rugby Laboratories, is $0.0374 per EA (NDC 00536121429), effective Aug 19, 2026.
How has the price of DIPHENHYDRAMINE 25 MG TABLET changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 25 MG TABLET has risen 8.8%. It has been tracked across 371 weekly CMS publications since Jul 17, 2019.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 25 MG TABLET?
Since Jul 17, 2019, the NADAC for DIPHENHYDRAMINE 25 MG TABLET has ranged from a low of $0.0299 (May 22, 2024) to a high of $0.0401 (Jul 12, 2023), with a median of $0.0355 per EA.
Are there cheaper alternatives to DIPHENHYDRAMINE 25 MG TABLET?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, SM ALLERGY (DIPHEN) 25 MG TAB, is $0.0358 per EA — about 4% below DIPHENHYDRAMINE 25 MG TABLET.
Who manufactures DIPHENHYDRAMINE 25 MG TABLET?
DIPHENHYDRAMINE 25 MG TABLET (NDC 00536121429) is labeled by Rugby Laboratories, and CMS classifies it as a generic product.