Product Information
DIPHENHYDRAMINE 12.5 MG/5 ML is a generic product labeled by Rising Pharma Holdings Inc., priced at $0.0174 per ML under NDC 57237030516. Its NADAC has been published 180 times since Apr 26, 2023.
Strength
12.5 mg/5mL
Manufacturer
Rising Pharma Holdings Inc.NDC
57237030516
Classification
Generic
Dosage Form
LIQUID
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M009.50On Market Since
12/19/2022
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has been published 180 times since Apr 26, 2023, and over the history we have for it it has declined 14.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0174 per ML |
|---|---|
| All-time high | $0.0204 (May 10, 2023) |
| All-time low | $0.0118 (Nov 20, 2024) |
| 52-week high | $0.0178 |
| 52-week low | $0.0123 |
| Median price | $0.0132 |
| Average price | $0.0142 |
| Largest weekly change | -27.1% (Mar 20, 2024) |
| Weeks tracked | 180 |
| Tracking since | Apr 26, 2023 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 11% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Rising Pharma Holdings Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Diphenhydramine Hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Histamine-1 Receptor Antagonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 12.5 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 12.5 MG/5 ML, manufactured by Rising Pharma Holdings Inc., is $0.0174 per ML (NDC 57237030516), effective Sep 30, 2026.
How has the price of DIPHENHYDRAMINE 12.5 MG/5 ML changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has declined 14.6%. It has been tracked across 180 weekly CMS publications since Apr 26, 2023.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 12.5 MG/5 ML?
Since Apr 26, 2023, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has ranged from a low of $0.0118 (Nov 20, 2024) to a high of $0.0204 (May 10, 2023), with a median of $0.0132 per ML.
Are there cheaper alternatives to DIPHENHYDRAMINE 12.5 MG/5 ML?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, QC CHILD ALLERGY 12.5 MG/5 ML, is $0.0155 per ML — about 11% below DIPHENHYDRAMINE 12.5 MG/5 ML.
Who manufactures DIPHENHYDRAMINE 12.5 MG/5 ML?
DIPHENHYDRAMINE 12.5 MG/5 ML (NDC 57237030516) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.