Product Information
DIPHENHYDRAMINE 50 MG/ML VIAL is a generic product labeled by Hikma Pharmaceuticals USA Inc., priced at $0.8980 per ML under NDC 00641628225. Its NADAC has been published 91 times since Jan 8, 2025.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AP.
Strength
50 mg/mL
Manufacturer
Hikma Pharmaceuticals USA Inc.NDC
00641628225
Classification
Generic
Dosage Form
INJECTION
Route
INTRAMUSCULAR; INTRAVENOUS
Effective Date
9/23/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA080817FDA Approved
Before 1982
TE Code
AP
On Market Since
11/27/1972
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 50 MG/ML VIAL has been published 91 times since Jan 8, 2025, and over the history we have for it it has held within roughly two percent of its current level. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.8980 per ML |
|---|---|
| All-time high | $0.9459 (Mar 11, 2026) |
| All-time low | $0.8837 (Jan 8, 2025) |
| 52-week high | $0.9459 |
| 52-week low | $0.8905 |
| Median price | $0.9276 |
| Average price | $0.9225 |
| Largest weekly change | -3.8% (Sep 23, 2026) |
| Weeks tracked | 91 |
| Tracking since | Jan 8, 2025 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 12% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Hikma Pharmaceuticals USA Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
diphenhydramine hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Histamine-1 Receptor Antagonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 50 MG/ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 50 MG/ML VIAL, manufactured by Hikma Pharmaceuticals USA Inc., is $0.8980 per ML (NDC 00641628225), effective Sep 30, 2026.
How has the price of DIPHENHYDRAMINE 50 MG/ML VIAL changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 50 MG/ML VIAL has held within roughly two percent of its current level. It has been tracked across 91 weekly CMS publications since Jan 8, 2025.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 50 MG/ML VIAL?
Since Jan 8, 2025, the NADAC for DIPHENHYDRAMINE 50 MG/ML VIAL has ranged from a low of $0.8837 (Jan 8, 2025) to a high of $0.9459 (Mar 11, 2026), with a median of $0.9276 per ML.
Are there cheaper alternatives to DIPHENHYDRAMINE 50 MG/ML VIAL?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DIPHENHYDRAMINE 500 MG/10 ML VL, is $0.7900 per ML — about 12% below DIPHENHYDRAMINE 50 MG/ML VIAL.
Who manufactures DIPHENHYDRAMINE 50 MG/ML VIAL?
DIPHENHYDRAMINE 50 MG/ML VIAL (NDC 00641628225) is labeled by Hikma Pharmaceuticals USA Inc., and CMS classifies it as a generic product.