Product Information
ESTRADIOL 0.05 MG PATCH (1/WK) is a generic product labeled by Sandoz Inc., priced at $10.8027 per EA under NDC 00781713354. Its NADAC has been published 407 times since Nov 7, 2018.
FDA first approved this application on Dec 22, 1994. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.05 mg/d
Manufacturer
Sandoz Inc.NDC
00781713354
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Authorized Generic (NDA)
FDA Application
NDA020375FDA Approved
12/22/1994
TE Code
AB2
On Market Since
12/22/1994
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has been published 407 times since Nov 7, 2018, and over the history we have for it it has declined 24.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $10.8027 per EA |
|---|---|
| All-time high | $14.5925 (Oct 16, 2019) |
| All-time low | $8.7935 (Jul 17, 2024) |
| 52-week high | $12.5223 |
| 52-week low | $10.6280 |
| Median price | $12.5223 |
| Average price | $12.4237 |
| Largest weekly change | +37.2% (Aug 21, 2024) |
| Weeks tracked | 407 |
| Tracking since | Nov 7, 2018 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 24% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.05 MG PATCH (1/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.05 MG PATCH (1/WK), manufactured by Sandoz Inc., is $10.8027 per EA (NDC 00781713354), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.05 MG PATCH (1/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has declined 24.0%. It has been tracked across 407 weekly CMS publications since Nov 7, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.05 MG PATCH (1/WK)?
Since Nov 7, 2018, the NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has ranged from a low of $8.7935 (Jul 17, 2024) to a high of $14.5925 (Oct 16, 2019), with a median of $12.5223 per EA.
Are there cheaper alternatives to ESTRADIOL 0.05 MG PATCH (1/WK)?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DOTTI 0.05 MG PATCH, is $8.2223 per EA — about 24% below ESTRADIOL 0.05 MG PATCH (1/WK).
Who manufactures ESTRADIOL 0.05 MG PATCH (1/WK)?
ESTRADIOL 0.05 MG PATCH (1/WK) (NDC 00781713354) is labeled by Sandoz Inc., and CMS classifies it as a generic product.