Product Information
ESTRADIOL 0.05 MG PATCH (1/WK) is a generic product labeled by Sandoz Inc., priced at $11.2827 per EA under NDC 00781713354. Its NADAC has been published 413 times since Nov 7, 2018.
FDA first approved this application on Dec 22, 1994. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.05 mg/d
Manufacturer
Sandoz Inc.NDC
00781713354
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Authorized Generic (NDA)
FDA Application
NDA020375FDA Approved
12/22/1994
TE Code
AB2
On Market Since
12/22/1994
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has been published 413 times since Nov 7, 2018, and over the history we have for it it has declined 20.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.2827 per EA |
|---|---|
| All-time high | $14.5925 (Oct 16, 2019) |
| All-time low | $8.7935 (Jul 17, 2024) |
| 52-week high | $12.5223 |
| 52-week low | $10.6280 |
| Median price | $12.5049 |
| Average price | $12.4025 |
| Largest weekly change | +37.2% (Aug 21, 2024) |
| Weeks tracked | 413 |
| Tracking since | Nov 7, 2018 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 25% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Sandoz Inc. manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.05 MG PATCH (1/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.05 MG PATCH (1/WK), manufactured by Sandoz Inc., is $11.2827 per EA (NDC 00781713354), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.05 MG PATCH (1/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has declined 20.6%. It has been tracked across 413 weekly CMS publications since Nov 7, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.05 MG PATCH (1/WK)?
Since Nov 7, 2018, the NADAC for ESTRADIOL 0.05 MG PATCH (1/WK) has ranged from a low of $8.7935 (Jul 17, 2024) to a high of $14.5925 (Oct 16, 2019), with a median of $12.5049 per EA.
Are there cheaper alternatives to ESTRADIOL 0.05 MG PATCH (1/WK)?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, LYLLANA 0.05 MG PATCH, is $8.5036 per EA — about 25% below ESTRADIOL 0.05 MG PATCH (1/WK).
Who manufactures ESTRADIOL 0.05 MG PATCH (1/WK)?
ESTRADIOL 0.05 MG PATCH (1/WK) (NDC 00781713354) is labeled by Sandoz Inc., and CMS classifies it as a generic product.