Product Information
ESTRADIOL 0.05 MG PATCH (2/WK) is a generic product labeled by Zydus Pharmaceuticals (USA) Inc., priced at $8.5036 per EA under NDC 70710119308. Its NADAC has been published 151 times since Nov 15, 2023.
FDA first approved this application on Dec 1, 2022. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.05 mg/d
Manufacturer
Zydus Pharmaceuticals (USA) Inc.NDC
70710119308
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA206241FDA Approved
12/1/2022
TE Code
AB1
On Market Since
4/13/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.05 MG PATCH (2/WK) has been published 151 times since Nov 15, 2023, and over the history we have for it it has risen 27.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.5036 per EA |
|---|---|
| All-time high | $8.5036 (Sep 30, 2026) |
| All-time low | $4.9914 (Nov 20, 2024) |
| 52-week high | $8.5036 |
| 52-week low | $7.1482 |
| Median price | $6.8561 |
| Average price | $6.8379 |
| Largest weekly change | +28.3% (Aug 21, 2024) |
| Weeks tracked | 151 |
| Tracking since | Nov 15, 2023 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Zydus Pharmaceuticals (USA) Inc. manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.05 MG PATCH (2/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.05 MG PATCH (2/WK), manufactured by Zydus Pharmaceuticals (USA) Inc., is $8.5036 per EA (NDC 70710119308), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.05 MG PATCH (2/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.05 MG PATCH (2/WK) has risen 27.2%. It has been tracked across 151 weekly CMS publications since Nov 15, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.05 MG PATCH (2/WK)?
Since Nov 15, 2023, the NADAC for ESTRADIOL 0.05 MG PATCH (2/WK) has ranged from a low of $4.9914 (Nov 20, 2024) to a high of $8.5036 (Sep 30, 2026), with a median of $6.8561 per EA.
Are there cheaper alternatives to ESTRADIOL 0.05 MG PATCH (2/WK)?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.05 MG PATCH (2/WK) in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.05 MG PATCH (2/WK)?
ESTRADIOL 0.05 MG PATCH (2/WK) (NDC 70710119308) is labeled by Zydus Pharmaceuticals (USA) Inc., and CMS classifies it as a generic product.