Product Information
BRIMONIDINE-TIMOLOL 0.2%-0.5% is a generic product labeled by Sandoz Inc., priced at $1.8390 per ML under NDC 00781718685. Its NADAC has been published 210 times since Aug 17, 2022.
FDA first approved this application on Apr 4, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; 5 mg/mL; mg/mL
Manufacturer
Sandoz Inc.NDC
00781718685
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
BRIMONIDINE TARTRATE; TIMOLOL MALEATEApproval Type
Generic (ANDA)
FDA Application
ANDA091087FDA Approved
4/4/2022
TE Code
AB
On Market Since
4/13/2022
Pharmacological Classes
Price Statistics
The NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has been published 210 times since Aug 17, 2022, and over the history we have for it it has declined 92.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.8390 per ML |
|---|---|
| All-time high | $30.7775 (Dec 14, 2022) |
| All-time low | $1.8390 (Aug 19, 2026) |
| 52-week high | $6.8975 |
| 52-week low | $1.8390 |
| Median price | $9.3179 |
| Average price | $11.3289 |
| Largest weekly change | +75.9% (Aug 21, 2024) |
| Weeks tracked | 210 |
| Tracking since | Aug 17, 2022 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BRIMONIDINE-TIMOLOL 0.2%-0.5%?
The current National Average Drug Acquisition Cost (NADAC) for BRIMONIDINE-TIMOLOL 0.2%-0.5%, manufactured by Sandoz Inc., is $1.8390 per ML (NDC 00781718685), effective Aug 19, 2026.
How has the price of BRIMONIDINE-TIMOLOL 0.2%-0.5% changed over time?
Over the history we have for it, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has declined 92.1%. It has been tracked across 210 weekly CMS publications since Aug 17, 2022.
What are the highest and lowest recorded NADAC prices for BRIMONIDINE-TIMOLOL 0.2%-0.5%?
Since Aug 17, 2022, the NADAC for BRIMONIDINE-TIMOLOL 0.2%-0.5% has ranged from a low of $1.8390 (Aug 19, 2026) to a high of $30.7775 (Dec 14, 2022), with a median of $9.3179 per ML.
Are there cheaper alternatives to BRIMONIDINE-TIMOLOL 0.2%-0.5%?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BRIMONIDINE-TIMOLOL 0.2%-0.5% in a comparable dosage form, but none are currently priced below it.
Who manufactures BRIMONIDINE-TIMOLOL 0.2%-0.5%?
BRIMONIDINE-TIMOLOL 0.2%-0.5% (NDC 00781718685) is labeled by Sandoz Inc., and CMS classifies it as a generic product.