Product Information
ROFLUMILAST 250 MCG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $1.9969 per EA under NDC 00904749371. Its NADAC has been published 36 times since Dec 17, 2025.
FDA first approved this application on Sep 7, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
250 ug/1
Manufacturer
Major PharmaceuticalsNDC
00904749371
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ROFLUMILASTApproval Type
Generic (ANDA)
FDA Application
ANDA208256FDA Approved
9/7/2022
TE Code
AB
On Market Since
10/27/2025
Pharmacological Classes
Price Statistics
The NADAC for ROFLUMILAST 250 MCG TABLET has been published 36 times since Dec 17, 2025, and over the history we have for it it has declined 12.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.9969 per EA |
|---|---|
| All-time high | $2.2887 (Jan 14, 2026) |
| All-time low | $1.9069 (Jun 17, 2026) |
| 52-week high | $2.2887 |
| 52-week low | $1.9069 |
| Median price | $2.0702 |
| Average price | $2.0853 |
| Largest weekly change | -8.5% (Apr 22, 2026) |
| Weeks tracked | 36 |
| Tracking since | Dec 17, 2025 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ROFLUMILAST 250 MCG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for ROFLUMILAST 250 MCG TABLET, manufactured by Major Pharmaceuticals, is $1.9969 per EA (NDC 00904749371), effective Aug 19, 2026.
How has the price of ROFLUMILAST 250 MCG TABLET changed over time?
Over the history we have for it, the NADAC for ROFLUMILAST 250 MCG TABLET has declined 12.8%. It has been tracked across 36 weekly CMS publications since Dec 17, 2025.
What are the highest and lowest recorded NADAC prices for ROFLUMILAST 250 MCG TABLET?
Since Dec 17, 2025, the NADAC for ROFLUMILAST 250 MCG TABLET has ranged from a low of $1.9069 (Jun 17, 2026) to a high of $2.2887 (Jan 14, 2026), with a median of $2.0702 per EA.
Are there cheaper alternatives to ROFLUMILAST 250 MCG TABLET?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ROFLUMILAST 250 MCG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures ROFLUMILAST 250 MCG TABLET?
ROFLUMILAST 250 MCG TABLET (NDC 00904749371) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.