Therapeutic Classes/Phosphodiesterase 4 Inhibitor

Phosphodiesterase 4 Inhibitor

37 drugs across 13 manufacturers|26 Generic,11 Brand

The Phosphodiesterase 4 Inhibitor class contains 37 NDCs from 13 manufacturers (26 generic, 11 brand), at an average NADAC of $9.00 per unit. Every drug, manufacturer, and price in this FDA-defined pharmacologic class is listed below.

Total Drugs

26G / 11B

Manufacturers

Avg $8.9985/unit

Avg 7d Change

-0.41%

Across 31 drugs with changes

7d Activity

6↑25↓6 flat

of 37 total drugs

Class Price Trend

Monthly average NADAC price per unit, split by generic and brand

Manufacturer Breakdown

13 manufacturers producing drugs in this therapeutic class(1 pricing outlier)

Major Pharmaceuticals

5 drugs

$0.6471

avg/unit

AstraZeneca Pharmaceuticals LP

4 drugs

$14.9431

avg/unit

Camber Pharmaceuticals Inc.

4 drugs

$1.1463

avg/unit

Zydus Pharmaceuticals (USA) Inc.

4 drugs

$1.1463

avg/unit

Novadoz Pharmaceuticals LLC

4 drugs

$1.1463

avg/unit

Arcutis Biotherapeutics, Inc.

Ascend Laboratories, LLC

2 drugs

$1.1463

avg/unit

Solco Healthcare US LLC

2 drugs

$0.3113

avg/unit

Aurobindo Pharma Limited

2 drugs

$0.3113

avg/unit

and 1 more manufacturer

Drug Portfolio

37 drugs total, 37 shown

Drug ↕	NDC	Price	7d Change ↕	Class	Market Outlier	Manufacturer ↕
OTEZLA 30 MG TABLET apremilast	55513013760	$90.5717 per EA	+0.03%	Brand	—	Amgen Inc.
OTEZLA 20 MG TABLET apremilast	55513049760	$89.9522 per EA	—	Brand	—	Amgen Inc.
ZORYVE 0.15% CREAM roflumilast	80610011560	$15.3987 per GM	+0.01%	Brand	High Outlier	Arcutis Biotherapeutics, Inc.
ZORYVE 0.3% CREAM roflumilast	80610013060	$15.3839 per GM	+0.03%	Brand	High Outlier	Arcutis Biotherapeutics, Inc.
ZORYVE 0.3% FOAM roflumilast	80610043060	$15.3778 per GM	0.00%	Brand	High Outlier	Arcutis Biotherapeutics, Inc.
DALIRESP 250 MCG TABLET roflumilast	00310008828	$14.9826 per EA	—	Brand	High Outlier	AstraZeneca Pharmaceuticals LP
DALIRESP 250 MCG TABLET roflumilast	00310008839	$14.9826 per EA	—	Brand	High Outlier	AstraZeneca Pharmaceuticals LP
DALIRESP 500 MCG TABLET roflumilast	00310009530	$14.9036 per EA	+0.01%	Brand	High Outlier	AstraZeneca Pharmaceuticals LP
DALIRESP 500 MCG TABLET roflumilast	00310009590	$14.9036 per EA	+0.01%	Brand	High Outlier	AstraZeneca Pharmaceuticals LP
EUCRISA 2% OINTMENT crisaborole	55724021121	$12.6465 per GM	0.00%	Brand	—	Pfizer Inc.
EUCRISA 2% OINTMENT crisaborole	55724021111	$10.7089 per GM	+0.17%	Brand	—	Pfizer Inc.
ROFLUMILAST 250 MCG TABLET Roflumilast	00904749371	$1.9813 per EA	-0.78%	Generic	—	Major Pharmaceuticals
ROFLUMILAST 250 MCG TABLET Roflumilast	31722067632	$1.9813 per EA	-0.78%	Generic	—	Camber Pharmaceuticals Inc.
ROFLUMILAST 250 MCG TABLET Roflumilast	31722067636	$1.9813 per EA	-0.78%	Generic	—	Camber Pharmaceuticals Inc.
ROFLUMILAST 250 MCG TABLET ROFLUMILAST	42571036983	$1.9813 per EA	-0.78%	Generic	—	Micro Labs Limited
ROFLUMILAST 250 MCG TABLET Roflumilast	67877073093	$1.9813 per EA	-0.78%	Generic	—	Ascend Laboratories, LLC
ROFLUMILAST 250 MCG TABLET Roflumilast	68382062431	$1.9813 per EA	-0.78%	Generic	—	Zydus Pharmaceuticals (USA) Inc.
ROFLUMILAST 250 MCG TABLET Roflumilast	68382062483	$1.9813 per EA	-0.78%	Generic	—	Zydus Pharmaceuticals (USA) Inc.
ROFLUMILAST 250 MCG TABLET Roflumilast	72205020124	$1.9813 per EA	-0.78%	Generic	—	Novadoz Pharmaceuticals LLC
ROFLUMILAST 250 MCG TABLET Roflumilast	72205020132	$1.9813 per EA	-0.78%	Generic	—	Novadoz Pharmaceuticals LLC
ROFLUMILAST 500 MCG TABLET Roflumilast	00904739989	$0.3204 per EA	—	Generic	—	Major Pharmaceuticals
ROFLUMILAST 500 MCG TABLET Roflumilast	00904739946	$0.3113 per EA	-1.50%	Generic	—	Major Pharmaceuticals
ROFLUMILAST 500 MCG TABLET Roflumilast	00904748303	$0.3113 per EA	-1.50%	Generic	—	Major Pharmaceuticals
ROFLUMILAST 500 MCG TABLET Roflumilast	00904748389	$0.3113 per EA	-1.50%	Generic	—	Major Pharmaceuticals
ROFLUMILAST 500 MCG TABLET Roflumilast	31722062330	$0.3113 per EA	-1.50%	Generic	—	Camber Pharmaceuticals Inc.
ROFLUMILAST 500 MCG TABLET Roflumilast	31722062390	$0.3113 per EA	-1.50%	Generic	—	Camber Pharmaceuticals Inc.
ROFLUMILAST 500 MCG TABLET Roflumilast	42571025930	$0.3113 per EA	-1.50%	Generic	—	Micro Labs Limited
ROFLUMILAST 500 MCG TABLET roflumilast	43547000503	$0.3113 per EA	-1.50%	Generic	—	Solco Healthcare US LLC
ROFLUMILAST 500 MCG TABLET roflumilast	43547000509	$0.3113 per EA	-1.50%	Generic	—	Solco Healthcare US LLC
ROFLUMILAST 500 MCG TABLET ROFLUMILAST	59651027530	$0.3113 per EA	-1.50%	Generic	—	Aurobindo Pharma Limited
ROFLUMILAST 500 MCG TABLET ROFLUMILAST	59651027590	$0.3113 per EA	-1.50%	Generic	—	Aurobindo Pharma Limited
ROFLUMILAST 500 MCG TABLET Roflumilast	60687078621	$0.3113 per EA	-1.50%	Generic	—	American Health Packaging
ROFLUMILAST 500 MCG TABLET Roflumilast	67877048090	$0.3113 per EA	-1.50%	Generic	—	Ascend Laboratories, LLC
ROFLUMILAST 500 MCG TABLET Roflumilast	68382096906	$0.3113 per EA	-1.50%	Generic	—	Zydus Pharmaceuticals (USA) Inc.
ROFLUMILAST 500 MCG TABLET Roflumilast	68382096916	$0.3113 per EA	-1.50%	Generic	—	Zydus Pharmaceuticals (USA) Inc.
ROFLUMILAST 500 MCG TABLET Roflumilast	72205020030	$0.3113 per EA	-1.50%	Generic	—	Novadoz Pharmaceuticals LLC
ROFLUMILAST 500 MCG TABLET Roflumilast	72205020090	$0.3113 per EA	-1.50%	Generic	—	Novadoz Pharmaceuticals LLC

Follow this class across the site

These links connect the therapeutic class page to the specific suppliers, markets, and trend surfaces that help users keep exploring.

Top supplier

Major Pharmaceuticals manufacturer profile

Review the supplier with the strongest product footprint inside this therapeutic class.

Lead market

Roflumilast market page

Move from the therapeutic class into the molecule that appears most often in this class-specific portfolio.

Trend hub

Latest trend hub

Compare this class against the rest of the weekly NADAC trend surface.

Guide

Understanding NADAC pricing

Use the explainer when you need a plain-English refresher on how these class-level numbers are published and interpreted.

Frequently Asked Questions

How many drugs are in the Phosphodiesterase 4 Inhibitor class?

The Phosphodiesterase 4 Inhibitor class contains 37 NDCs from 13 manufacturers — 26 generic and 11 brand products.

What is the average price of Phosphodiesterase 4 Inhibitor drugs?

The average NADAC for the Phosphodiesterase 4 Inhibitor class is $8.9985 per unit across 37 NDCs.

Is generic cheaper than brand in the Phosphodiesterase 4 Inhibitor class?

Among products priced per EA, the average generic NADAC in this class is $0.8897, versus $40.0494 for brand — brand products average about 45× the generic price.

Which manufacturers make Phosphodiesterase 4 Inhibitor drugs?

13 manufacturers make drugs in the Phosphodiesterase 4 Inhibitor class. Ranked by number of NDCs, the largest are Major Pharmaceuticals (5), AstraZeneca Pharmaceuticals LP (4), Camber Pharmaceuticals Inc. (4), Zydus Pharmaceuticals (USA) Inc. (4), Novadoz Pharmaceuticals LLC (4).

How has Phosphodiesterase 4 Inhibitor pricing changed recently?

Over the past 7 days, 6 NDCs in this class rose and 25 fell, with a class-wide average change of -0.4%.