Product Information
CLOBETASOL 0.05% SOLUTION is a generic product labeled by Encube Ethicals, Inc., priced at $0.1359 per ML under NDC 21922006127. Its NADAC has been published 118 times since Jul 3, 2024.
FDA first approved this application on Aug 5, 2005. Its Orange Book therapeutic-equivalence code is AT.
Strength
.5 mg/mL
Manufacturer
Encube Ethicals, Inc.NDC
21922006127
Classification
Generic
Dosage Form
SOLUTION
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
CLOBETASOL PROPIONATEApproval Type
Generic (ANDA)
FDA Application
ANDA076977FDA Approved
8/5/2005
TE Code
AT
On Market Since
6/10/2024
Pharmacological Classes
Price Statistics
The NADAC for CLOBETASOL 0.05% SOLUTION has been published 118 times since Jul 3, 2024, and over the history we have for it it has declined 22.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1359 per ML |
|---|---|
| All-time high | $0.2506 (Oct 16, 2024) |
| All-time low | $0.1149 (May 20, 2026) |
| 52-week high | $0.1829 |
| 52-week low | $0.1149 |
| Median price | $0.1738 |
| Average price | $0.1630 |
| Largest weekly change | -19.4% (Oct 23, 2024) |
| Weeks tracked | 118 |
| Tracking since | Jul 3, 2024 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 11% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
clobetasol propionate market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of CLOBETASOL 0.05% SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for CLOBETASOL 0.05% SOLUTION, manufactured by Encube Ethicals, Inc., is $0.1359 per ML (NDC 21922006127), effective Sep 30, 2026.
How has the price of CLOBETASOL 0.05% SOLUTION changed over time?
Over the history we have for it, the NADAC for CLOBETASOL 0.05% SOLUTION has declined 22.9%. It has been tracked across 118 weekly CMS publications since Jul 3, 2024.
What are the highest and lowest recorded NADAC prices for CLOBETASOL 0.05% SOLUTION?
Since Jul 3, 2024, the NADAC for CLOBETASOL 0.05% SOLUTION has ranged from a low of $0.1149 (May 20, 2026) to a high of $0.2506 (Oct 16, 2024), with a median of $0.1738 per ML.
Are there cheaper alternatives to CLOBETASOL 0.05% SOLUTION?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CLOBETASOL 0.05% SOLUTION, is $0.1204 per ML — about 11% below CLOBETASOL 0.05% SOLUTION.
Who manufactures CLOBETASOL 0.05% SOLUTION?
CLOBETASOL 0.05% SOLUTION (NDC 21922006127) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.