Product Information
CLOBETASOL 0.05% SOLUTION is a generic product labeled by Encube Ethicals, Inc., priced at $0.1345 per ML under NDC 21922006127. Its NADAC has been published 112 times since Jul 3, 2024.
FDA first approved this application on Aug 5, 2005. Its Orange Book therapeutic-equivalence code is AT.
Strength
.5 mg/mL
Manufacturer
Encube Ethicals, Inc.NDC
21922006127
Classification
Generic
Dosage Form
SOLUTION
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
CLOBETASOL PROPIONATEApproval Type
Generic (ANDA)
FDA Application
ANDA076977FDA Approved
8/5/2005
TE Code
AT
On Market Since
6/10/2024
Pharmacological Classes
Price Statistics
The NADAC for CLOBETASOL 0.05% SOLUTION has been published 112 times since Jul 3, 2024, and over the history we have for it it has declined 23.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1345 per ML |
|---|---|
| All-time high | $0.2506 (Oct 16, 2024) |
| All-time low | $0.1149 (May 20, 2026) |
| 52-week high | $0.1917 |
| 52-week low | $0.1149 |
| Median price | $0.1745 |
| Average price | $0.1645 |
| Largest weekly change | -19.4% (Oct 23, 2024) |
| Weeks tracked | 112 |
| Tracking since | Jul 3, 2024 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 10% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of CLOBETASOL 0.05% SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for CLOBETASOL 0.05% SOLUTION, manufactured by Encube Ethicals, Inc., is $0.1345 per ML (NDC 21922006127), effective Aug 19, 2026.
How has the price of CLOBETASOL 0.05% SOLUTION changed over time?
Over the history we have for it, the NADAC for CLOBETASOL 0.05% SOLUTION has declined 23.6%. It has been tracked across 112 weekly CMS publications since Jul 3, 2024.
What are the highest and lowest recorded NADAC prices for CLOBETASOL 0.05% SOLUTION?
Since Jul 3, 2024, the NADAC for CLOBETASOL 0.05% SOLUTION has ranged from a low of $0.1149 (May 20, 2026) to a high of $0.2506 (Oct 16, 2024), with a median of $0.1745 per ML.
Are there cheaper alternatives to CLOBETASOL 0.05% SOLUTION?
Yes. 4 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CLOBETASOL 0.05% SOLUTION, is $0.1204 per ML — about 10% below CLOBETASOL 0.05% SOLUTION.
Who manufactures CLOBETASOL 0.05% SOLUTION?
CLOBETASOL 0.05% SOLUTION (NDC 21922006127) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.