Product Information
ESTRADIOL 0.1% (1 MG) GEL PKT is a generic product labeled by Encube Ethicals, Inc., priced at $0.9673 per GM under NDC 21922008952. Its NADAC has been published 43 times since Dec 10, 2025.
FDA first approved this application on Mar 5, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922008952
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA218507FDA Approved
3/5/2025
TE Code
AB
On Market Since
3/10/2025
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has been published 43 times since Dec 10, 2025, and over the history we have for it it has declined 45.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9673 per GM |
|---|---|
| All-time high | $1.7779 (Dec 10, 2025) |
| All-time low | $0.9673 (Sep 23, 2026) |
| 52-week high | $1.7779 |
| 52-week low | $0.9673 |
| Median price | $1.5746 |
| Average price | $1.5005 |
| Largest weekly change | -15.1% (Jul 22, 2026) |
| Weeks tracked | 43 |
| Tracking since | Dec 10, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Encube Ethicals, Inc. manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1 MG) GEL PKT, manufactured by Encube Ethicals, Inc., is $0.9673 per GM (NDC 21922008952), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (1 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has declined 45.6%. It has been tracked across 43 weekly CMS publications since Dec 10, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1 MG) GEL PKT?
Since Dec 10, 2025, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has ranged from a low of $0.9673 (Sep 23, 2026) to a high of $1.7779 (Dec 10, 2025), with a median of $1.5746 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1 MG) GEL PKT?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (1 MG) GEL PKT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (1 MG) GEL PKT?
ESTRADIOL 0.1% (1 MG) GEL PKT (NDC 21922008952) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.