Product Information
ESTRADIOL 0.1% (1 MG) GEL PKT is a generic product labeled by Encube Ethicals, Inc., priced at $1.1272 per GM under NDC 21922008952. Its NADAC has been published 37 times since Dec 10, 2025.
FDA first approved this application on Mar 5, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Encube Ethicals, Inc.NDC
21922008952
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA218507FDA Approved
3/5/2025
TE Code
AB
On Market Since
3/10/2025
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has been published 37 times since Dec 10, 2025, and over the history we have for it it has declined 36.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.1272 per GM |
|---|---|
| All-time high | $1.7779 (Dec 10, 2025) |
| All-time low | $1.1272 (Aug 19, 2026) |
| 52-week high | $1.7779 |
| 52-week low | $1.1272 |
| Median price | $1.5964 |
| Average price | $1.5697 |
| Largest weekly change | -15.1% (Jul 22, 2026) |
| Weeks tracked | 37 |
| Tracking since | Dec 10, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1 MG) GEL PKT, manufactured by Encube Ethicals, Inc., is $1.1272 per GM (NDC 21922008952), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.1% (1 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has declined 36.6%. It has been tracked across 37 weekly CMS publications since Dec 10, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1 MG) GEL PKT?
Since Dec 10, 2025, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has ranged from a low of $1.1272 (Aug 19, 2026) to a high of $1.7779 (Dec 10, 2025), with a median of $1.5964 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1 MG) GEL PKT?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (1 MG) GEL PKT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (1 MG) GEL PKT?
ESTRADIOL 0.1% (1 MG) GEL PKT (NDC 21922008952) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.