Product Information
ISTALOL 0.5% EYE DROPS is a brand product labeled by Bausch & Lomb Incorporated, priced at $80.0146 per ML under NDC 24208000403. Its NADAC has been published 514 times since Nov 28, 2013.
FDA first approved this application on Jun 4, 2004. Its Orange Book therapeutic-equivalence code is AT2.
The High Outlier badge above means this manufacturer's average price in the Timolol Maleate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
5 mg/mL
Manufacturer
Bausch & Lomb IncorporatedNDC
24208000403
Classification
Brand
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
7/22/2026
Active Ingredients
TIMOLOL MALEATEApproval Type
New Drug (NDA)
FDA Application
NDA021516FDA Approved
6/4/2004
TE Code
AT2
On Market Since
8/2/2004
Pharmacological Classes
Price Statistics
The NADAC for ISTALOL 0.5% EYE DROPS has been published 514 times since Nov 28, 2013, and over the history we have for it it has risen 106.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $80.0146 per ML |
|---|---|
| All-time high | $80.1365 (Aug 13, 2025) |
| All-time low | $38.6690 (Nov 28, 2013) |
| 52-week high | $80.1191 |
| 52-week low | $80.0092 |
| Median price | $62.5090 |
| Average price | $63.7727 |
| Largest weekly change | +10.0% (Jan 14, 2015) |
| Weeks tracked | 514 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 78% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ISTALOL 0.5% EYE DROPS?
The current National Average Drug Acquisition Cost (NADAC) for ISTALOL 0.5% EYE DROPS, manufactured by Bausch & Lomb Incorporated, is $80.0146 per ML (NDC 24208000403), effective Aug 19, 2026.
How has the price of ISTALOL 0.5% EYE DROPS changed over time?
Over the history we have for it, the NADAC for ISTALOL 0.5% EYE DROPS has risen 106.9%. It has been tracked across 514 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for ISTALOL 0.5% EYE DROPS?
Since Nov 28, 2013, the NADAC for ISTALOL 0.5% EYE DROPS has ranged from a low of $38.6690 (Nov 28, 2013) to a high of $80.1365 (Aug 13, 2025), with a median of $62.5090 per ML.
Are there cheaper alternatives to ISTALOL 0.5% EYE DROPS?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TIMOLOL 0.5% EYE DROP, is $17.7216 per ML — about 78% below ISTALOL 0.5% EYE DROPS.
Who manufactures ISTALOL 0.5% EYE DROPS?
ISTALOL 0.5% EYE DROPS (NDC 24208000403) is labeled by Bausch & Lomb Incorporated, and CMS classifies it as a brand product.