Product Information
HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET is a generic product labeled by Rhodes Pharmaceuticals L.P., priced at $0.1523 per EA under NDC 42858020350. Its NADAC has been published 542 times since May 18, 2016.
FDA first approved this application on Apr 12, 2016. Its Orange Book therapeutic-equivalence code is AA.
Strength
325; 10 mg/1; mg/1
Manufacturer
Rhodes Pharmaceuticals L.P.NDC
42858020350
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHEN; HYDROCODONE BITARTRATEApproval Type
Generic (ANDA)
FDA Application
ANDA202991FDA Approved
4/12/2016
TE Code
AA
On Market Since
4/12/2016
Pharmacological Classes
Price Statistics
The NADAC for HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET has been published 542 times since May 18, 2016, and over the history we have for it it has declined 16.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1523 per EA |
|---|---|
| All-time high | $0.1992 (Oct 12, 2016) |
| All-time low | $0.1075 (Nov 20, 2019) |
| 52-week high | $0.1607 |
| 52-week low | $0.1522 |
| Median price | $0.1392 |
| Average price | $0.1441 |
| Largest weekly change | +17.4% (Jun 19, 2024) |
| Weeks tracked | 542 |
| Tracking since | May 18, 2016 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 12% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Rhodes Pharmaceuticals L.P. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Hydrocodone Bitartrate and Acetaminophen market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Opioid Agonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET, manufactured by Rhodes Pharmaceuticals L.P., is $0.1523 per EA (NDC 42858020350), effective Sep 30, 2026.
How has the price of HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET changed over time?
Over the history we have for it, the NADAC for HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET has declined 16.8%. It has been tracked across 542 weekly CMS publications since May 18, 2016.
What are the highest and lowest recorded NADAC prices for HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET?
Since May 18, 2016, the NADAC for HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET has ranged from a low of $0.1075 (Nov 20, 2019) to a high of $0.1992 (Oct 12, 2016), with a median of $0.1392 per EA.
Are there cheaper alternatives to HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET?
Yes. 12 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET, is $0.1347 per EA — about 12% below HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET.
Who manufactures HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET?
HYDROCODONE-ACETAMINOPHEN 10-325 MG TABLET (NDC 42858020350) is labeled by Rhodes Pharmaceuticals L.P., and CMS classifies it as a generic product.