Product Information
HYDROCORTISONE 2.5% CREAM is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $0.0955 per GM under NDC 45802000403. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AT.
Strength
25 mg/g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802000403
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
HYDROCORTISONEApproval Type
Generic (ANDA)
FDA Application
ANDA085025FDA Approved
Before 1982
TE Code
AT
On Market Since
3/31/2006
Pharmacological Classes
Price Statistics
The NADAC for HYDROCORTISONE 2.5% CREAM has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 2.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0955 per GM |
|---|---|
| All-time high | $0.1222 (Aug 13, 2025) |
| All-time low | $0.0761 (Sep 21, 2022) |
| 52-week high | $0.1210 |
| 52-week low | $0.0955 |
| Median price | $0.0951 |
| Average price | $0.0979 |
| Largest weekly change | +22.6% (Feb 22, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 16% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
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Drug market
Hydrocortisone market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of HYDROCORTISONE 2.5% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for HYDROCORTISONE 2.5% CREAM, manufactured by Padagis Israel Pharmaceuticals Ltd, is $0.0955 per GM (NDC 45802000403), effective Sep 30, 2026.
How has the price of HYDROCORTISONE 2.5% CREAM changed over time?
Over the history we have for it, the NADAC for HYDROCORTISONE 2.5% CREAM has declined 2.8%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for HYDROCORTISONE 2.5% CREAM?
Since Nov 28, 2013, the NADAC for HYDROCORTISONE 2.5% CREAM has ranged from a low of $0.0761 (Sep 21, 2022) to a high of $0.1222 (Aug 13, 2025), with a median of $0.0951 per GM.
Are there cheaper alternatives to HYDROCORTISONE 2.5% CREAM?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, HYDROCORTISONE 2.5% CREAM, is $0.0799 per GM — about 16% below HYDROCORTISONE 2.5% CREAM.
Who manufactures HYDROCORTISONE 2.5% CREAM?
HYDROCORTISONE 2.5% CREAM (NDC 45802000403) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.