Product Information
OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET is a generic product labeled by Amneal Pharmaceuticals of New York LLC, priced at $0.2308 per EA under NDC 53746020405. Its NADAC has been published 529 times since Aug 17, 2016.
FDA first approved this application on Nov 27, 2007. Its Orange Book therapeutic-equivalence code is AA.
Strength
325; 10 mg/1; mg/1
Manufacturer
Amneal Pharmaceuticals of New York LLCNDC
53746020405
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ACETAMINOPHEN; OXYCODONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA040778FDA Approved
11/27/2007
TE Code
AA
On Market Since
11/27/2007
Pharmacological Classes
Price Statistics
The NADAC for OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET has been published 529 times since Aug 17, 2016, and over the history we have for it it has declined 61.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.2308 per EA |
|---|---|
| All-time high | $0.6026 (Sep 14, 2016) |
| All-time low | $0.1580 (Sep 22, 2021) |
| 52-week high | $0.2472 |
| 52-week low | $0.2292 |
| Median price | $0.2370 |
| Average price | $0.2677 |
| Largest weekly change | -22.1% (Nov 20, 2024) |
| Weeks tracked | 529 |
| Tracking since | Aug 17, 2016 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 22% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals of New York LLC manufacturer profile
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Drug market
Oxycodone and Acetaminophen market comparison
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Therapeutic class
Opioid Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET, manufactured by Amneal Pharmaceuticals of New York LLC, is $0.2308 per EA (NDC 53746020405), effective Sep 30, 2026.
How has the price of OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET changed over time?
Over the history we have for it, the NADAC for OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET has declined 61.7%. It has been tracked across 529 weekly CMS publications since Aug 17, 2016.
What are the highest and lowest recorded NADAC prices for OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET?
Since Aug 17, 2016, the NADAC for OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET has ranged from a low of $0.1580 (Sep 22, 2021) to a high of $0.6026 (Sep 14, 2016), with a median of $0.2370 per EA.
Are there cheaper alternatives to OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET?
Yes. 12 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET, is $0.1796 per EA — about 22% below OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET.
Who manufactures OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET?
OXYCODONE-ACETAMINOPHEN 10-325 MG TABLET (NDC 53746020405) is labeled by Amneal Pharmaceuticals of New York LLC, and CMS classifies it as a generic product.