Product Information
OTREXUP 20 MG/0.4 ML AUTO-INJ is a brand product labeled by Antares Pharma, Inc., priced at $480.8553 per ML under NDC 54436002004. Its NADAC has been published 203 times since Dec 23, 2015.
The High Outlier badge above means this manufacturer's average price in the methotrexate market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
20 mg/.4mL
Manufacturer
Antares Pharma, Inc.NDC
54436002004
Classification
Brand
Dosage Form
INJECTION, SOLUTION
Route
SUBCUTANEOUS
Last Updated
4/1/2025
Active Ingredients
METHOTREXATEApproval Type
New Drug (NDA)
FDA Application
NDA204824On Market Since
10/11/2013
Pharmacological Classes
Price Statistics
The NADAC for OTREXUP 20 MG/0.4 ML AUTO-INJ has been published 203 times since Dec 23, 2015, and over the history we have for it it has risen 42.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $480.8553 per ML |
|---|---|
| All-time high | $480.8553 (Apr 15, 2026) |
| All-time low | $337.2800 (Dec 23, 2015) |
| 52-week high | $480.8553 |
| 52-week low | $480.8553 |
| Median price | $466.5647 |
| Average price | $429.8682 |
| Largest weekly change | +18.3% (Apr 17, 2024) |
| Weeks tracked | 203 |
| Tracking since | Dec 23, 2015 |
Generic Alternatives
The matcher finds 1 NADAC-published product sharing this drug's active ingredient, strength, and dosage form across 1 manufacturer (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 25% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of OTREXUP 20 MG/0.4 ML AUTO-INJ?
The current National Average Drug Acquisition Cost (NADAC) for OTREXUP 20 MG/0.4 ML AUTO-INJ, manufactured by Antares Pharma, Inc., is $480.8553 per ML (NDC 54436002004), effective Apr 15, 2026.
How has the price of OTREXUP 20 MG/0.4 ML AUTO-INJ changed over time?
Over the history we have for it, the NADAC for OTREXUP 20 MG/0.4 ML AUTO-INJ has risen 42.6%. It has been tracked across 203 weekly CMS publications since Dec 23, 2015.
What are the highest and lowest recorded NADAC prices for OTREXUP 20 MG/0.4 ML AUTO-INJ?
Since Dec 23, 2015, the NADAC for OTREXUP 20 MG/0.4 ML AUTO-INJ has ranged from a low of $337.2800 (Dec 23, 2015) to a high of $480.8553 (Apr 15, 2026), with a median of $466.5647 per ML.
Are there cheaper alternatives to OTREXUP 20 MG/0.4 ML AUTO-INJ?
Yes. 1 NADAC-published product shares the same active ingredient, strength, and dosage form. The lowest-priced option, RASUVO 20 MG/0.4 ML AUTOINJ, is $361.0282 per ML — about 25% below OTREXUP 20 MG/0.4 ML AUTO-INJ.
Who manufactures OTREXUP 20 MG/0.4 ML AUTO-INJ?
OTREXUP 20 MG/0.4 ML AUTO-INJ (NDC 54436002004) is labeled by Antares Pharma, Inc., and CMS classifies it as a brand product.
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