Methotrexate
38 NDCs across 16 manufacturers|23 Generic,15 Brand
Methotrexate is used to treat juvenile arthritis, rheumatoid arthritis, breast neoplasms, choriocarcinoma, crohn disease and esophageal neoplasms, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on Oct 11, 2013. In 2024, Medicare Part D spent $246K on Methotrexate across 238 claims for 84 beneficiaries.
Methotrexate is available as 38 NDCs from 16 manufacturers (23 generic, 15 brand), with NADAC prices from $0.65 to $960.29 per ML — the most expensive product costs about 1,489× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Active FDA drug shortage
14 Methotrexate presentations are currently listed in FDA's drug shortage database (first posted Mar 13, 2023). Shortages can move NADAC prices in the following weeks.
Total NDCs
38
23G / 15B
Manufacturers
16
competing in market
Price Spread
$0.65 – $960.29
per ML, 24 of 38 NDCs
7d Activity
avg +1.0% WoW · of 38 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Explore this market from other angles
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Top supplier
Medexus Pharma Inc. manufacturer profile
Open the supplier page for the manufacturer with the strongest footprint in this market.
Lead class
Folate Analog Metabolic Inhibitor class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
16 manufacturers producing METHOTREXATE(2 pricing outliers)
Frequently Asked Questions
What is Methotrexate used to treat?
Methotrexate is used to treat juvenile arthritis, rheumatoid arthritis, breast neoplasms, choriocarcinoma, crohn disease and esophageal neoplasms, per the National Library of Medicine's MED-RT classification.
How much does Medicare spend on Methotrexate?
In 2024, Medicare Part D spent $246K on Methotrexate across 238 claims for 84 beneficiaries.
Is Methotrexate in shortage?
Yes — FDA's drug shortage database currently lists 14 Methotrexate presentations with status "Current", first posted Mar 13, 2023.
How many Methotrexate products are on the market?
The Methotrexate drug market contains 38 NDCs from 16 manufacturers — 23 generic and 15 brand products.
What is the price range for Methotrexate?
NADAC reference prices for Methotrexate range from $0.6450 to $960.2932 per ML — the most expensive product costs about 1,489× the cheapest. 14 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.
Is generic Methotrexate cheaper than brand?
The average generic NADAC for Methotrexate is $1.5314 per ML, versus $478.1794 for brand-labeled products — brand versions average about 312× the generic price.
Which manufacturers make Methotrexate?
16 manufacturers list Methotrexate in NADAC. Ranked by number of NDCs, the largest are Medexus Pharma Inc. (7), Hospira Inc. (5), Antares Pharma, Inc. (4), Accord Healthcare Inc. (4), Teva Women's Health, Inc. (3).
How has the price of Methotrexate changed recently?
Over the past 7 days, 18 Methotrexate NDCs rose and 2 fell, with a market-wide average change of +1.0%.