Product Information
GLYBURIDE-METFORMIN 2.5-500 MG is a generic product labeled by Rising Pharma Holdings Inc., priced at $0.1715 per EA under NDC 57237002401. Its NADAC has been published 652 times since Apr 9, 2014.
FDA first approved this application on Nov 14, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2.5; 500 mg/1; mg/1
Manufacturer
Rising Pharma Holdings Inc.NDC
57237002401
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
GLYBURIDE; METFORMIN HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA077870FDA Approved
11/14/2007
TE Code
AB
On Market Since
11/14/2007
Pharmacological Classes
Price Statistics
The NADAC for GLYBURIDE-METFORMIN 2.5-500 MG has been published 652 times since Apr 9, 2014, and over the history we have for it it has risen 93.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1715 per EA |
|---|---|
| All-time high | $0.2036 (Mar 11, 2026) |
| All-time low | $0.0337 (Dec 20, 2023) |
| 52-week high | $0.2036 |
| 52-week low | $0.1663 |
| Median price | $0.0562 |
| Average price | $0.0718 |
| Largest weekly change | +57.9% (Jan 17, 2024) |
| Weeks tracked | 652 |
| Tracking since | Apr 9, 2014 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Rising Pharma Holdings Inc. manufacturer profile
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Drug market
Glyburide and Metformin Hydrochloride market comparison
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Therapeutic class
Biguanide class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of GLYBURIDE-METFORMIN 2.5-500 MG?
The current National Average Drug Acquisition Cost (NADAC) for GLYBURIDE-METFORMIN 2.5-500 MG, manufactured by Rising Pharma Holdings Inc., is $0.1715 per EA (NDC 57237002401), effective Sep 30, 2026.
How has the price of GLYBURIDE-METFORMIN 2.5-500 MG changed over time?
Over the history we have for it, the NADAC for GLYBURIDE-METFORMIN 2.5-500 MG has risen 93.3%. It has been tracked across 652 weekly CMS publications since Apr 9, 2014.
What are the highest and lowest recorded NADAC prices for GLYBURIDE-METFORMIN 2.5-500 MG?
Since Apr 9, 2014, the NADAC for GLYBURIDE-METFORMIN 2.5-500 MG has ranged from a low of $0.0337 (Dec 20, 2023) to a high of $0.2036 (Mar 11, 2026), with a median of $0.0562 per EA.
Are there cheaper alternatives to GLYBURIDE-METFORMIN 2.5-500 MG?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as GLYBURIDE-METFORMIN 2.5-500 MG in a comparable dosage form, but none are currently priced below it.
Who manufactures GLYBURIDE-METFORMIN 2.5-500 MG?
GLYBURIDE-METFORMIN 2.5-500 MG (NDC 57237002401) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.