Product Information
ESTRADIOL 10 MCG VAGINAL INSRT is a generic product labeled by Aurobindo Pharma Limited, priced at $5.5180 per EA under NDC 59651043918. Its NADAC has been published 71 times since May 28, 2025.
FDA first approved this application on Aug 2, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10 ug/1
Manufacturer
Aurobindo Pharma LimitedNDC
59651043918
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
VAGINAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOL HEMIHYDRATEApproval Type
Generic (ANDA)
FDA Application
ANDA216550FDA Approved
8/2/2024
TE Code
AB
On Market Since
8/2/2024
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 10 MCG VAGINAL INSRT has been published 71 times since May 28, 2025, and over the history we have for it it has declined 23.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $5.5180 per EA |
|---|---|
| All-time high | $7.1953 (Jun 11, 2025) |
| All-time low | $5.5180 (Sep 23, 2026) |
| 52-week high | $7.0095 |
| 52-week low | $5.5180 |
| Median price | $6.8480 |
| Average price | $6.6195 |
| Largest weekly change | -4.7% (Apr 22, 2026) |
| Weeks tracked | 71 |
| Tracking since | May 28, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Aurobindo Pharma Limited manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Estradiol market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 10 MCG VAGINAL INSRT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 10 MCG VAGINAL INSRT, manufactured by Aurobindo Pharma Limited, is $5.5180 per EA (NDC 59651043918), effective Sep 30, 2026.
How has the price of ESTRADIOL 10 MCG VAGINAL INSRT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 10 MCG VAGINAL INSRT has declined 23.3%. It has been tracked across 71 weekly CMS publications since May 28, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 10 MCG VAGINAL INSRT?
Since May 28, 2025, the NADAC for ESTRADIOL 10 MCG VAGINAL INSRT has ranged from a low of $5.5180 (Sep 23, 2026) to a high of $7.1953 (Jun 11, 2025), with a median of $6.8480 per EA.
Are there cheaper alternatives to ESTRADIOL 10 MCG VAGINAL INSRT?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 10 MCG VAGINAL INSRT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 10 MCG VAGINAL INSRT?
ESTRADIOL 10 MCG VAGINAL INSRT (NDC 59651043918) is labeled by Aurobindo Pharma Limited, and CMS classifies it as a generic product.