Product Information
DOTTI 0.025 MG PATCH is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $7.7577 per EA under NDC 65162098908. Its NADAC has been published 378 times since Jul 10, 2019.
FDA first approved this application on Feb 4, 2019. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.025 mg/d
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162098908
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211293FDA Approved
2/4/2019
TE Code
AB1
On Market Since
2/4/2019
Pharmacological Classes
Price Statistics
The NADAC for DOTTI 0.025 MG PATCH has been published 378 times since Jul 10, 2019, and over the history we have for it it has declined 5.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $7.7577 per EA |
|---|---|
| All-time high | $10.9520 (Jan 12, 2022) |
| All-time low | $4.9692 (Nov 20, 2024) |
| 52-week high | $7.8302 |
| 52-week low | $6.2985 |
| Median price | $7.0257 |
| Average price | $7.2120 |
| Largest weekly change | +47.0% (Dec 22, 2021) |
| Weeks tracked | 378 |
| Tracking since | Jul 10, 2019 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
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Drug market
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of DOTTI 0.025 MG PATCH?
The current National Average Drug Acquisition Cost (NADAC) for DOTTI 0.025 MG PATCH, manufactured by Amneal Pharmaceuticals LLC, is $7.7577 per EA (NDC 65162098908), effective Sep 30, 2026.
How has the price of DOTTI 0.025 MG PATCH changed over time?
Over the history we have for it, the NADAC for DOTTI 0.025 MG PATCH has declined 5.6%. It has been tracked across 378 weekly CMS publications since Jul 10, 2019.
What are the highest and lowest recorded NADAC prices for DOTTI 0.025 MG PATCH?
Since Jul 10, 2019, the NADAC for DOTTI 0.025 MG PATCH has ranged from a low of $4.9692 (Nov 20, 2024) to a high of $10.9520 (Jan 12, 2022), with a median of $7.0257 per EA.
Are there cheaper alternatives to DOTTI 0.025 MG PATCH?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as DOTTI 0.025 MG PATCH in a comparable dosage form, but none are currently priced below it.
Who manufactures DOTTI 0.025 MG PATCH?
DOTTI 0.025 MG PATCH (NDC 65162098908) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.