Product Information
DIVIGEL 0.25 MG GEL PACKET is a brand product labeled by Vertical Pharmaceuticals, LLC, priced at $5.3880 per EA under NDC 68025006530. Its NADAC has been published 559 times since Jul 22, 2015.
FDA first approved this application on Jun 4, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
Vertical Pharmaceuticals, LLCNDC
68025006530
Classification
Brand
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA022038FDA Approved
6/4/2007
TE Code
AB
On Market Since
10/27/2014
Pharmacological Classes
Price Statistics
The NADAC for DIVIGEL 0.25 MG GEL PACKET has been published 559 times since Jul 22, 2015, and over the history we have for it it has risen 69.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $5.3880 per EA |
|---|---|
| All-time high | $5.4088 (Oct 11, 2023) |
| All-time low | $3.1851 (Jul 22, 2015) |
| 52-week high | $5.4032 |
| 52-week low | $5.3866 |
| Median price | $4.5618 |
| Average price | $4.5673 |
| Largest weekly change | +8.1% (Feb 22, 2017) |
| Weeks tracked | 559 |
| Tracking since | Jul 22, 2015 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 86% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Vertical Pharmaceuticals, LLC manufacturer profile
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Drug market
estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIVIGEL 0.25 MG GEL PACKET?
The current National Average Drug Acquisition Cost (NADAC) for DIVIGEL 0.25 MG GEL PACKET, manufactured by Vertical Pharmaceuticals, LLC, is $5.3880 per EA (NDC 68025006530), effective Sep 30, 2026.
How has the price of DIVIGEL 0.25 MG GEL PACKET changed over time?
Over the history we have for it, the NADAC for DIVIGEL 0.25 MG GEL PACKET has risen 69.2%. It has been tracked across 559 weekly CMS publications since Jul 22, 2015.
What are the highest and lowest recorded NADAC prices for DIVIGEL 0.25 MG GEL PACKET?
Since Jul 22, 2015, the NADAC for DIVIGEL 0.25 MG GEL PACKET has ranged from a low of $3.1851 (Jul 22, 2015) to a high of $5.4088 (Oct 11, 2023), with a median of $4.5618 per EA.
Are there cheaper alternatives to DIVIGEL 0.25 MG GEL PACKET?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ESTRADIOL 0.1% (0.25 MG) GEL PK, is $0.7570 per EA — about 86% below DIVIGEL 0.25 MG GEL PACKET.
Who manufactures DIVIGEL 0.25 MG GEL PACKET?
DIVIGEL 0.25 MG GEL PACKET (NDC 68025006530) is labeled by Vertical Pharmaceuticals, LLC, and CMS classifies it as a brand product.