Product Information
PREMARIN 1.25 MG TABLET is a brand product labeled by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., priced at $6.9562 per EA under NDC 00046110491. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1.25 mg/1
NDC
00046110491
Classification
Brand
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
ESTROGENS, CONJUGATEDApproval Type
New Drug (NDA)
FDA Application
NDA004782FDA Approved
Before 1982
TE Code
AB
On Market Since
9/1/2004
Pharmacological Classes
Price Statistics
The NADAC for PREMARIN 1.25 MG TABLET has been published 665 times since Nov 28, 2013, and over the history we have for it it has risen 153.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $6.9562 per EA |
|---|---|
| All-time high | $6.9578 (Jul 15, 2026) |
| All-time low | $2.7422 (Nov 28, 2013) |
| 52-week high | $6.9578 |
| 52-week low | $6.7660 |
| Median price | $5.6718 |
| Average price | $5.4152 |
| Largest weekly change | +9.4% (Jun 11, 2014) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 19% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PREMARIN 1.25 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for PREMARIN 1.25 MG TABLET, manufactured by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., is $6.9562 per EA (NDC 00046110491), effective Aug 19, 2026.
How has the price of PREMARIN 1.25 MG TABLET changed over time?
Over the history we have for it, the NADAC for PREMARIN 1.25 MG TABLET has risen 153.7%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PREMARIN 1.25 MG TABLET?
Since Nov 28, 2013, the NADAC for PREMARIN 1.25 MG TABLET has ranged from a low of $2.7422 (Nov 28, 2013) to a high of $6.9578 (Jul 15, 2026), with a median of $5.6718 per EA.
Are there cheaper alternatives to PREMARIN 1.25 MG TABLET?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CONJUGATED ESTROGENS 1.25 MG TB, is $5.6026 per EA — about 19% below PREMARIN 1.25 MG TABLET.
Who manufactures PREMARIN 1.25 MG TABLET?
PREMARIN 1.25 MG TABLET (NDC 00046110491) is labeled by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., and CMS classifies it as a brand product.