Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $0.7570 per EA under NDC 45802013430. Its NADAC has been published 139 times since Feb 7, 2024.
FDA first approved this application on Nov 14, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802013430
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216524FDA Approved
11/14/2023
TE Code
AB
On Market Since
12/7/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 139 times since Feb 7, 2024, and over the history we have for it it has declined 80.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7570 per EA |
|---|---|
| All-time high | $3.7861 (Apr 10, 2024) |
| All-time low | $0.7570 (Sep 23, 2026) |
| 52-week high | $1.9622 |
| 52-week low | $0.7570 |
| Median price | $1.7226 |
| Average price | $1.8675 |
| Largest weekly change | +54.8% (Sep 18, 2024) |
| Weeks tracked | 139 |
| Tracking since | Feb 7, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
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Drug market
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by Padagis Israel Pharmaceuticals Ltd, is $0.7570 per EA (NDC 45802013430), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 80.0%. It has been tracked across 139 weekly CMS publications since Feb 7, 2024.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Feb 7, 2024, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $0.7570 (Sep 23, 2026) to a high of $3.7861 (Apr 10, 2024), with a median of $1.7226 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (0.25 MG) GEL PK in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 45802013430) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.