Product Information
SIROLIMUS 0.5 MG TABLET is a generic product labeled by Zydus Pharmaceuticals (USA) Inc., priced at $0.8415 per EA under NDC 68382052001. Its NADAC has been published 650 times since Apr 23, 2014.
FDA first approved this application on Jan 8, 2014. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/1
Manufacturer
Zydus Pharmaceuticals (USA) Inc.NDC
68382052001
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
SIROLIMUSApproval Type
Generic (ANDA)
FDA Application
ANDA201676FDA Approved
1/8/2014
TE Code
AB
On Market Since
1/15/2014
Pharmacological Classes
Price Statistics
The NADAC for SIROLIMUS 0.5 MG TABLET has been published 650 times since Apr 23, 2014, and over the history we have for it it has declined 86.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.8415 per EA |
|---|---|
| All-time high | $6.5979 (Feb 15, 2017) |
| All-time low | $0.8415 (Sep 23, 2026) |
| 52-week high | $1.8025 |
| 52-week low | $0.8415 |
| Median price | $5.2645 |
| Average price | $4.6763 |
| Largest weekly change | -50.5% (Sep 20, 2023) |
| Weeks tracked | 650 |
| Tracking since | Apr 23, 2014 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Zydus Pharmaceuticals (USA) Inc. manufacturer profile
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Drug market
sirolimus market comparison
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Therapeutic class
Kinase Inhibitor class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of SIROLIMUS 0.5 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for SIROLIMUS 0.5 MG TABLET, manufactured by Zydus Pharmaceuticals (USA) Inc., is $0.8415 per EA (NDC 68382052001), effective Sep 30, 2026.
How has the price of SIROLIMUS 0.5 MG TABLET changed over time?
Over the history we have for it, the NADAC for SIROLIMUS 0.5 MG TABLET has declined 86.5%. It has been tracked across 650 weekly CMS publications since Apr 23, 2014.
What are the highest and lowest recorded NADAC prices for SIROLIMUS 0.5 MG TABLET?
Since Apr 23, 2014, the NADAC for SIROLIMUS 0.5 MG TABLET has ranged from a low of $0.8415 (Sep 23, 2026) to a high of $6.5979 (Feb 15, 2017), with a median of $5.2645 per EA.
Are there cheaper alternatives to SIROLIMUS 0.5 MG TABLET?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as SIROLIMUS 0.5 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures SIROLIMUS 0.5 MG TABLET?
SIROLIMUS 0.5 MG TABLET (NDC 68382052001) is labeled by Zydus Pharmaceuticals (USA) Inc., and CMS classifies it as a generic product.