Sirolimus

27 NDCs across 14 manufacturers|27 Generic,0 Brand

Sirolimus is used to treat lymphangioleiomyomatosis and perivascular epithelioid cell neoplasms, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved on Sep 15, 1999, and the first generic was approved Jan 8, 2014. FDA's Orange Book lists 14 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $19 million on Sirolimus across 41,000 claims for 8,298 beneficiaries.

Sirolimus is available as 27 NDCs from 14 manufacturers (27 generic, 0 brand), with NADAC prices from $0.84 to $2.64 per EA — the most expensive product costs about 3.2× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

27G / 0B

Manufacturers

competing in market

Price Spread

$0.84 – $2.64

per EA, 20 of 27 NDCs

7d Activity

54↓-27 flat

avg -6.4% WoW · of 27 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

14 manufacturers producing SIROLIMUS

Mylan Pharmaceuticals Inc.

4 NDCs

$2.2445

avg/unit

Glenmark Pharmaceuticals Inc., USA

3 NDCs

$1.4716

avg/unit

Zydus Pharmaceuticals (USA) Inc.

3 NDCs

$1.4716

avg/unit

Ascend Laboratories, LLC

3 NDCs

$1.4716

avg/unit

Dr. Reddy's Laboratories Inc.

2 NDCs

$1.7382

avg/unit

Camber Pharmaceuticals Inc.

Amneal Pharmaceuticals NY LLC

1 NDC

$4.5633

avg/unit

Novadoz Pharmaceuticals LLC

1 NDC

$4.5633

avg/unit

Major Pharmaceuticals

1 NDC

$0.8350

avg/unit

American Health Packaging

Drug Portfolio

27 NDCs total, 27 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
SIROLIMUS 1 MG/ML SOLUTION	72603040901	NorthStar Rx LLC	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG/ML SOLUTION	31722031631	Camber Pharmaceuticals Inc.	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG/ML SOLUTION	59762120506	Mylan Pharmaceuticals Inc.	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG/ML SOLUTION	60505619702	Apotex Corp.	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG/ML SOLUTION	66689034702	VistaPharm, LLC	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG/ML SOLUTION	69238159403	Amneal Pharmaceuticals NY LLC	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG/ML SOLUTION	72205009978	Novadoz Pharmaceuticals LLC	$4.5633 per ML	—	Generic	-7.02%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 2 MG TABLET	68462068401	Glenmark Pharmaceuticals Inc., USA	$2.6413 per EA	—	Generic	-5.90%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 2 MG TABLET	68382035201	Zydus Pharmaceuticals (USA) Inc.	$2.6413 per EA	—	Generic	-5.90%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 2 MG TABLET	16714018901	NorthStar Rx LLC	$2.6413 per EA	—	Generic	-5.90%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 2 MG TABLET	55111065401	Dr. Reddy's Laboratories Inc.	$2.6413 per EA	—	Generic	-5.90%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 2 MG TABLET	67877074801	Ascend Laboratories, LLC	$2.6413 per EA	—	Generic	-5.90%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 2 MG TABLET	59762100301	Mylan Pharmaceuticals Inc.	$2.6413 per EA	—	Generic	-5.90%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 0.5 MG TABLET	68462068201	Glenmark Pharmaceuticals Inc., USA	$0.9386 per EA	—	Generic	-9.37%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 0.5 MG TABLET	68382052001	Zydus Pharmaceuticals (USA) Inc.	$0.9386 per EA	—	Generic	-9.37%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 0.5 MG TABLET	16714018701	NorthStar Rx LLC	$0.9386 per EA	—	Generic	-9.37%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 0.5 MG TABLET	67877074601	Ascend Laboratories, LLC	$0.9386 per EA	—	Generic	-9.37%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 0.5 MG TABLET	59762100101	Mylan Pharmaceuticals Inc.	$0.9386 per EA	—	Generic	-9.37%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	55111065301	Dr. Reddy's Laboratories Inc.	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	59762100201	Mylan Pharmaceuticals Inc.	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	68462068301	Glenmark Pharmaceuticals Inc., USA	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	00904724804	Major Pharmaceuticals	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	67877074701	Ascend Laboratories, LLC	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	68084091525	American Health Packaging	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	68382035101	Zydus Pharmaceuticals (USA) Inc.	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	16714018801	NorthStar Rx LLC	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant
SIROLIMUS 1 MG TABLET	50268071813	AvPAK	$0.8350 per EA	—	Generic	-4.57%	Kinase Inhibitor, mTOR Inhibitor Immunosuppressant

Frequently Asked Questions

What is Sirolimus used to treat?

Sirolimus is used to treat lymphangioleiomyomatosis and perivascular epithelioid cell neoplasms, per the National Library of Medicine's MED-RT classification.

When did Sirolimus become available as a generic?

FDA approved the first generic Sirolimus (ANDA) on Jan 8, 2014. The Orange Book currently lists 14 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Sirolimus?

In 2024, Medicare Part D spent $19 million on Sirolimus across 41,000 claims for 8,298 beneficiaries.

How many Sirolimus products are on the market?

The Sirolimus drug market contains 27 NDCs from 14 manufacturers — 27 generic and 0 brand products.

What is the price range for Sirolimus?

NADAC reference prices for Sirolimus range from $0.8350 to $2.6413 per EA — the most expensive product costs about 3.2× the cheapest. 7 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Which manufacturers make Sirolimus?

14 manufacturers list Sirolimus in NADAC. Ranked by number of NDCs, the largest are NorthStar Rx LLC (4), Mylan Pharmaceuticals Inc. (4), Glenmark Pharmaceuticals Inc., USA (3), Zydus Pharmaceuticals (USA) Inc. (3), Ascend Laboratories, LLC (3).

How has the price of Sirolimus changed recently?

Over the past 7 days, 0 Sirolimus NDCs rose and 54 fell, with a market-wide average change of -6.4%.