Product Information
ESTRADIOL 0.1% (0.5 MG) GEL PKT is a generic product labeled by Amneal Pharmaceuticals NY LLC, priced at $0.9548 per EA under NDC 69238245103. Its NADAC has been published 92 times since Jan 1, 2025.
FDA first approved this application on Jul 12, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.5 mg/.5g
Manufacturer
Amneal Pharmaceuticals NY LLCNDC
69238245103
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216055FDA Approved
7/12/2024
TE Code
AB
On Market Since
7/15/2024
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has been published 92 times since Jan 1, 2025, and over the history we have for it it has declined 39.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9548 per EA |
|---|---|
| All-time high | $2.1810 (Jul 16, 2025) |
| All-time low | $0.9548 (Sep 23, 2026) |
| 52-week high | $2.0017 |
| 52-week low | $0.9548 |
| Median price | $1.8329 |
| Average price | $1.7086 |
| Largest weekly change | -17.4% (Aug 19, 2026) |
| Weeks tracked | 92 |
| Tracking since | Jan 1, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Transdermal market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Amneal Pharmaceuticals NY LLC manufacturer profile
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Drug market
Estradiol Transdermal market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.5 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.5 MG) GEL PKT, manufactured by Amneal Pharmaceuticals NY LLC, is $0.9548 per EA (NDC 69238245103), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.5 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has declined 39.8%. It has been tracked across 92 weekly CMS publications since Jan 1, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.5 MG) GEL PKT?
Since Jan 1, 2025, the NADAC for ESTRADIOL 0.1% (0.5 MG) GEL PKT has ranged from a low of $0.9548 (Sep 23, 2026) to a high of $2.1810 (Jul 16, 2025), with a median of $1.8329 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.5 MG) GEL PKT?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (0.5 MG) GEL PKT in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (0.5 MG) GEL PKT?
ESTRADIOL 0.1% (0.5 MG) GEL PKT (NDC 69238245103) is labeled by Amneal Pharmaceuticals NY LLC, and CMS classifies it as a generic product.