Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by Amneal Pharmaceuticals NY LLC, priced at $0.7570 per EA under NDC 69238245203. Its NADAC has been published 87 times since Feb 5, 2025.
FDA first approved this application on Jul 12, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
Amneal Pharmaceuticals NY LLCNDC
69238245203
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216055FDA Approved
7/12/2024
TE Code
AB
On Market Since
7/15/2024
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 87 times since Feb 5, 2025, and over the history we have for it it has declined 52.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7570 per EA |
|---|---|
| All-time high | $2.0942 (Aug 13, 2025) |
| All-time low | $0.7570 (Sep 23, 2026) |
| 52-week high | $1.9622 |
| 52-week low | $0.7570 |
| Median price | $1.7120 |
| Average price | $1.6666 |
| Largest weekly change | -24.2% (Aug 19, 2026) |
| Weeks tracked | 87 |
| Tracking since | Feb 5, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Transdermal market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Amneal Pharmaceuticals NY LLC manufacturer profile
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Drug market
Estradiol Transdermal market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by Amneal Pharmaceuticals NY LLC, is $0.7570 per EA (NDC 69238245203), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 52.1%. It has been tracked across 87 weekly CMS publications since Feb 5, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Feb 5, 2025, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $0.7570 (Sep 23, 2026) to a high of $2.0942 (Aug 13, 2025), with a median of $1.7120 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (0.25 MG) GEL PK in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 69238245203) is labeled by Amneal Pharmaceuticals NY LLC, and CMS classifies it as a generic product.