Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by Amneal Pharmaceuticals NY LLC, priced at $0.8636 per EA under NDC 69238245203. Its NADAC has been published 81 times since Feb 5, 2025.
FDA first approved this application on Jul 12, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
Amneal Pharmaceuticals NY LLCNDC
69238245203
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216055FDA Approved
7/12/2024
TE Code
AB
On Market Since
7/15/2024
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 81 times since Feb 5, 2025, and over the history we have for it it has declined 45.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.8636 per EA |
|---|---|
| All-time high | $2.0942 (Aug 13, 2025) |
| All-time low | $0.8636 (Aug 19, 2026) |
| 52-week high | $2.0353 |
| 52-week low | $0.8636 |
| Median price | $1.7226 |
| Average price | $1.7287 |
| Largest weekly change | -24.2% (Aug 19, 2026) |
| Weeks tracked | 81 |
| Tracking since | Feb 5, 2025 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Transdermal market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by Amneal Pharmaceuticals NY LLC, is $0.8636 per EA (NDC 69238245203), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 45.3%. It has been tracked across 81 weekly CMS publications since Feb 5, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Feb 5, 2025, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $0.8636 (Aug 19, 2026) to a high of $2.0942 (Aug 13, 2025), with a median of $1.7226 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (0.25 MG) GEL PK in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 69238245203) is labeled by Amneal Pharmaceuticals NY LLC, and CMS classifies it as a generic product.