Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by Xiromed LLC, priced at $0.8636 per EA under NDC 70700014335. Its NADAC has been published 149 times since Oct 18, 2023.
FDA first approved this application on Aug 10, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
Xiromed LLCNDC
70700014335
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211783FDA Approved
8/10/2022
TE Code
AB
On Market Since
10/1/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 149 times since Oct 18, 2023, and over the history we have for it it has declined 74.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.8636 per EA |
|---|---|
| All-time high | $3.7861 (Apr 10, 2024) |
| All-time low | $0.8636 (Aug 19, 2026) |
| 52-week high | $2.0353 |
| 52-week low | $0.8636 |
| Median price | $1.8151 |
| Average price | $2.0647 |
| Largest weekly change | +54.8% (Sep 18, 2024) |
| Weeks tracked | 149 |
| Tracking since | Oct 18, 2023 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Gel 0.1% market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by Xiromed LLC, is $0.8636 per EA (NDC 70700014335), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 74.7%. It has been tracked across 149 weekly CMS publications since Oct 18, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Oct 18, 2023, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $0.8636 (Aug 19, 2026) to a high of $3.7861 (Apr 10, 2024), with a median of $1.8151 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (0.25 MG) GEL PK in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 70700014335) is labeled by Xiromed LLC, and CMS classifies it as a generic product.