Product Information
ESTRADIOL 0.1% (1 MG) GEL PKT is a generic product labeled by Xiromed LLC, priced at $0.9673 per GM under NDC 70700014535. Its NADAC has been published 189 times since Feb 22, 2023.
FDA first approved this application on Aug 10, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Xiromed LLCNDC
70700014535
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211783FDA Approved
8/10/2022
TE Code
AB
On Market Since
10/1/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has been published 189 times since Feb 22, 2023, and over the history we have for it it has declined 72.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9673 per GM |
|---|---|
| All-time high | $4.0103 (Oct 11, 2023) |
| All-time low | $0.9673 (Sep 23, 2026) |
| 52-week high | $1.9348 |
| 52-week low | $0.9673 |
| Median price | $2.0186 |
| Average price | $2.4085 |
| Largest weekly change | -55.7% (Apr 17, 2024) |
| Weeks tracked | 189 |
| Tracking since | Feb 22, 2023 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Gel 0.1% market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Xiromed LLC manufacturer profile
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Drug market
Estradiol Gel 0.1% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1 MG) GEL PKT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1 MG) GEL PKT, manufactured by Xiromed LLC, is $0.9673 per GM (NDC 70700014535), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (1 MG) GEL PKT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has declined 72.1%. It has been tracked across 189 weekly CMS publications since Feb 22, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1 MG) GEL PKT?
Since Feb 22, 2023, the NADAC for ESTRADIOL 0.1% (1 MG) GEL PKT has ranged from a low of $0.9673 (Sep 23, 2026) to a high of $4.0103 (Oct 11, 2023), with a median of $2.0186 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1 MG) GEL PKT?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (1 MG) GEL PKT in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (1 MG) GEL PKT?
ESTRADIOL 0.1% (1 MG) GEL PKT (NDC 70700014535) is labeled by Xiromed LLC, and CMS classifies it as a generic product.