Product Information
ESTRADIOL 0.1% (0.75 MG) GEL PK is a generic product labeled by Xiromed LLC, priced at $0.5919 per EA under NDC 70700019435. Its NADAC has been published 168 times since Jul 19, 2023.
FDA first approved this application on Aug 10, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.75 mg/.75g
Manufacturer
Xiromed LLCNDC
70700019435
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211783FDA Approved
8/10/2022
TE Code
AB
On Market Since
10/1/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.75 MG) GEL PK has been published 168 times since Jul 19, 2023, and over the history we have for it it has declined 83.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5919 per EA |
|---|---|
| All-time high | $3.6639 (May 15, 2024) |
| All-time low | $0.5919 (Sep 23, 2026) |
| 52-week high | $2.1132 |
| 52-week low | $0.5919 |
| Median price | $2.0178 |
| Average price | $2.2630 |
| Largest weekly change | -44.9% (May 22, 2024) |
| Weeks tracked | 168 |
| Tracking since | Jul 19, 2023 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Gel 0.1% market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Xiromed LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Estradiol Gel 0.1% market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.75 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.75 MG) GEL PK, manufactured by Xiromed LLC, is $0.5919 per EA (NDC 70700019435), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.75 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.75 MG) GEL PK has declined 83.7%. It has been tracked across 168 weekly CMS publications since Jul 19, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.75 MG) GEL PK?
Since Jul 19, 2023, the NADAC for ESTRADIOL 0.1% (0.75 MG) GEL PK has ranged from a low of $0.5919 (Sep 23, 2026) to a high of $3.6639 (May 15, 2024), with a median of $2.0178 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.75 MG) GEL PK?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (0.75 MG) GEL PK in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (0.75 MG) GEL PK?
ESTRADIOL 0.1% (0.75 MG) GEL PK (NDC 70700019435) is labeled by Xiromed LLC, and CMS classifies it as a generic product.