Product Information
ESTRADIOL 0.1% (1.25 MG) GEL PK is a generic product labeled by Xiromed LLC, priced at $0.7335 per GM under NDC 70700019535. Its NADAC has been published 137 times since Feb 21, 2024.
FDA first approved this application on Aug 10, 2022. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1.25 mg/1.25g
Manufacturer
Xiromed LLCNDC
70700019535
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211783FDA Approved
8/10/2022
TE Code
AB
On Market Since
10/1/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has been published 137 times since Feb 21, 2024, and over the history we have for it it has declined 70.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7335 per GM |
|---|---|
| All-time high | $2.8779 (Jun 12, 2024) |
| All-time low | $0.7335 (Sep 23, 2026) |
| 52-week high | $1.6751 |
| 52-week low | $0.7335 |
| Median price | $1.5635 |
| Average price | $1.5893 |
| Largest weekly change | -30.5% (Jun 19, 2024) |
| Weeks tracked | 137 |
| Tracking since | Feb 21, 2024 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Estradiol Gel 0.1% market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Xiromed LLC manufacturer profile
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Drug market
Estradiol Gel 0.1% market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1.25 MG) GEL PK, manufactured by Xiromed LLC, is $0.7335 per GM (NDC 70700019535), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (1.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has declined 70.7%. It has been tracked across 137 weekly CMS publications since Feb 21, 2024.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1.25 MG) GEL PK?
Since Feb 21, 2024, the NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has ranged from a low of $0.7335 (Sep 23, 2026) to a high of $2.8779 (Jun 12, 2024), with a median of $1.5635 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1.25 MG) GEL PK?
No other NADAC-published product currently shares the active ingredient and strength of ESTRADIOL 0.1% (1.25 MG) GEL PK in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures ESTRADIOL 0.1% (1.25 MG) GEL PK?
ESTRADIOL 0.1% (1.25 MG) GEL PK (NDC 70700019535) is labeled by Xiromed LLC, and CMS classifies it as a generic product.