Product Information
LOPERAMIDE 2 MG CAPSULE is a generic product labeled by NorthStar Rx LLC, priced at $0.0549 per EA under NDC 72603032801. Its NADAC has been published 71 times since May 28, 2025.
FDA first approved this application on Sep 5, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2 mg/1
Manufacturer
NorthStar Rx LLCNDC
72603032801
Classification
Generic
Dosage Form
CAPSULE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
LOPERAMIDE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA218122FDA Approved
9/5/2023
TE Code
AB
On Market Since
12/1/2024
Pharmacological Classes
Price Statistics
The NADAC for LOPERAMIDE 2 MG CAPSULE has been published 71 times since May 28, 2025, and over the history we have for it it has declined 50.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0549 per EA |
|---|---|
| All-time high | $0.1160 (Jul 16, 2025) |
| All-time low | $0.0520 (Feb 18, 2026) |
| 52-week high | $0.0798 |
| 52-week low | $0.0520 |
| Median price | $0.0565 |
| Average price | $0.0699 |
| Largest weekly change | -20.7% (Sep 17, 2025) |
| Weeks tracked | 71 |
| Tracking since | May 28, 2025 |
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
NorthStar Rx LLC manufacturer profile
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Drug market
LOPERAMIDE HYDROCHLORIDE market comparison
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Therapeutic class
Opioid Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LOPERAMIDE 2 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for LOPERAMIDE 2 MG CAPSULE, manufactured by NorthStar Rx LLC, is $0.0549 per EA (NDC 72603032801), effective Sep 30, 2026.
How has the price of LOPERAMIDE 2 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for LOPERAMIDE 2 MG CAPSULE has declined 50.8%. It has been tracked across 71 weekly CMS publications since May 28, 2025.
What are the highest and lowest recorded NADAC prices for LOPERAMIDE 2 MG CAPSULE?
Since May 28, 2025, the NADAC for LOPERAMIDE 2 MG CAPSULE has ranged from a low of $0.0520 (Feb 18, 2026) to a high of $0.1160 (Jul 16, 2025), with a median of $0.0565 per EA.
Are there cheaper alternatives to LOPERAMIDE 2 MG CAPSULE?
7 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LOPERAMIDE 2 MG CAPSULE in a comparable dosage form, but none are currently priced below it.
Who manufactures LOPERAMIDE 2 MG CAPSULE?
LOPERAMIDE 2 MG CAPSULE (NDC 72603032801) is labeled by NorthStar Rx LLC, and CMS classifies it as a generic product.