Product Information
PHENYLEPHRINE 2.5% EYE DROP is a generic product labeled by NorthStar Rx LLC, priced at $9.2924 per ML under NDC 72603052001. Its NADAC has been published 79 times since Apr 2, 2025.
FDA first approved this application on Sep 29, 2022. Its Orange Book therapeutic-equivalence code is AT.
Strength
25 mg/mL
Manufacturer
NorthStar Rx LLCNDC
72603052001
Classification
Generic
Dosage Form
SOLUTION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
PHENYLEPHRINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA216859FDA Approved
9/29/2022
TE Code
AT
On Market Since
10/1/2024
Pharmacological Classes
Price Statistics
The NADAC for PHENYLEPHRINE 2.5% EYE DROP has been published 79 times since Apr 2, 2025, and over the history we have for it it has declined 29.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $9.2924 per ML |
|---|---|
| All-time high | $13.1832 (Apr 16, 2025) |
| All-time low | $8.5534 (Feb 18, 2026) |
| 52-week high | $12.2873 |
| 52-week low | $8.5534 |
| Median price | $9.2765 |
| Average price | $10.5448 |
| Largest weekly change | -12.0% (Nov 19, 2025) |
| Weeks tracked | 79 |
| Tracking since | Apr 2, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
NorthStar Rx LLC manufacturer profile
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Drug market
Phenylephrine Hydrochloride market comparison
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Therapeutic class
alpha-1 Adrenergic Agonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PHENYLEPHRINE 2.5% EYE DROP?
The current National Average Drug Acquisition Cost (NADAC) for PHENYLEPHRINE 2.5% EYE DROP, manufactured by NorthStar Rx LLC, is $9.2924 per ML (NDC 72603052001), effective Sep 30, 2026.
How has the price of PHENYLEPHRINE 2.5% EYE DROP changed over time?
Over the history we have for it, the NADAC for PHENYLEPHRINE 2.5% EYE DROP has declined 29.5%. It has been tracked across 79 weekly CMS publications since Apr 2, 2025.
What are the highest and lowest recorded NADAC prices for PHENYLEPHRINE 2.5% EYE DROP?
Since Apr 2, 2025, the NADAC for PHENYLEPHRINE 2.5% EYE DROP has ranged from a low of $8.5534 (Feb 18, 2026) to a high of $13.1832 (Apr 16, 2025), with a median of $9.2765 per ML.
Are there cheaper alternatives to PHENYLEPHRINE 2.5% EYE DROP?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as PHENYLEPHRINE 2.5% EYE DROP in a comparable dosage form, but none are currently priced below it.
Who manufactures PHENYLEPHRINE 2.5% EYE DROP?
PHENYLEPHRINE 2.5% EYE DROP (NDC 72603052001) is labeled by NorthStar Rx LLC, and CMS classifies it as a generic product.