Product Information
AMITRIPTYLINE HCL 50 MG TAB is a generic product labeled by Advagen Pharma Ltd., priced at $0.0904 per EA under NDC 72888006900. Its NADAC has been published 72 times since Apr 9, 2025.
FDA first approved this application on May 1, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/1
Manufacturer
Advagen Pharma Ltd.NDC
72888006900
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
AMITRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA215376FDA Approved
5/1/2023
TE Code
AB
On Market Since
5/1/2023
Pharmacological Classes
Price Statistics
The NADAC for AMITRIPTYLINE HCL 50 MG TAB has been published 72 times since Apr 9, 2025, and over the history we have for it it has risen 5.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0904 per EA |
|---|---|
| All-time high | $0.1019 (Jun 10, 2026) |
| All-time low | $0.0859 (Apr 9, 2025) |
| 52-week high | $0.1019 |
| 52-week low | $0.0889 |
| Median price | $0.0932 |
| Average price | $0.0939 |
| Largest weekly change | +8.3% (May 21, 2025) |
| Weeks tracked | 72 |
| Tracking since | Apr 9, 2025 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of AMITRIPTYLINE HCL 50 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for AMITRIPTYLINE HCL 50 MG TAB, manufactured by Advagen Pharma Ltd., is $0.0904 per EA (NDC 72888006900), effective Aug 19, 2026.
How has the price of AMITRIPTYLINE HCL 50 MG TAB changed over time?
Over the history we have for it, the NADAC for AMITRIPTYLINE HCL 50 MG TAB has risen 5.3%. It has been tracked across 72 weekly CMS publications since Apr 9, 2025.
What are the highest and lowest recorded NADAC prices for AMITRIPTYLINE HCL 50 MG TAB?
Since Apr 9, 2025, the NADAC for AMITRIPTYLINE HCL 50 MG TAB has ranged from a low of $0.0859 (Apr 9, 2025) to a high of $0.1019 (Jun 10, 2026), with a median of $0.0932 per EA.
Are there cheaper alternatives to AMITRIPTYLINE HCL 50 MG TAB?
12 manufacturers publish a NADAC-priced product with the same active ingredient and strength as AMITRIPTYLINE HCL 50 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures AMITRIPTYLINE HCL 50 MG TAB?
AMITRIPTYLINE HCL 50 MG TAB (NDC 72888006900) is labeled by Advagen Pharma Ltd., and CMS classifies it as a generic product.