Product Information
DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY is a generic product labeled by Trifluent Pharma LLC, priced at $29.4355 per ML under NDC 73352009619. Its NADAC has been published 51 times since Oct 15, 2025.
FDA first approved this application on Jun 22, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
4 mg/mL
Manufacturer
Trifluent Pharma LLCNDC
73352009619
Classification
Generic
Dosage Form
SPRAY
Route
NASAL
Effective Date
9/23/2026
Active Ingredients
DIHYDROERGOTAMINE MESYLATEApproval Type
Generic (ANDA)
FDA Application
ANDA216881FDA Approved
6/22/2023
TE Code
AB
On Market Since
7/8/2025
Pharmacological Classes
Price Statistics
The NADAC for DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY has been published 51 times since Oct 15, 2025, and over the history we have for it it has declined 10.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $29.4355 per ML |
|---|---|
| All-time high | $35.4287 (May 13, 2026) |
| All-time low | $29.4355 (Sep 23, 2026) |
| 52-week high | $35.4287 |
| 52-week low | $29.4355 |
| Median price | $33.2164 |
| Average price | $32.9412 |
| Largest weekly change | -6.5% (Jul 22, 2026) |
| Weeks tracked | 51 |
| Tracking since | Oct 15, 2025 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Trifluent Pharma LLC manufacturer profile
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Drug market
Dihydroergotamine mesylate market comparison
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Therapeutic class
Ergotamine Derivative class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY?
The current National Average Drug Acquisition Cost (NADAC) for DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY, manufactured by Trifluent Pharma LLC, is $29.4355 per ML (NDC 73352009619), effective Sep 30, 2026.
How has the price of DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY changed over time?
Over the history we have for it, the NADAC for DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY has declined 10.2%. It has been tracked across 51 weekly CMS publications since Oct 15, 2025.
What are the highest and lowest recorded NADAC prices for DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY?
Since Oct 15, 2025, the NADAC for DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY has ranged from a low of $29.4355 (Sep 23, 2026) to a high of $35.4287 (May 13, 2026), with a median of $33.2164 per ML.
Are there cheaper alternatives to DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY in a comparable dosage form, but none are currently priced below it.
Who manufactures DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY?
DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY (NDC 73352009619) is labeled by Trifluent Pharma LLC, and CMS classifies it as a generic product.