Product Information
DIPHENHYDRAMINE 12.5 MG/5 ML is a generic product labeled by Oncor Pharmaceuticals, priced at $0.0174 per ML under NDC 83720050216. Its NADAC has been published 73 times since May 14, 2025.
Strength
12.5 mg/5mL
Manufacturer
Oncor PharmaceuticalsNDC
83720050216
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M012On Market Since
3/27/2025
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has been published 73 times since May 14, 2025, and over the history we have for it it has risen 43.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0174 per ML |
|---|---|
| All-time high | $0.0178 (Feb 11, 2026) |
| All-time low | $0.0121 (Jun 18, 2025) |
| 52-week high | $0.0178 |
| 52-week low | $0.0123 |
| Median price | $0.0168 |
| Average price | $0.0152 |
| Largest weekly change | +17.4% (Nov 19, 2025) |
| Weeks tracked | 73 |
| Tracking since | May 14, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 18% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Oncor Pharmaceuticals manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Diphenhydramine Hydrochloride market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Histamine-1 Receptor Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 12.5 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 12.5 MG/5 ML, manufactured by Oncor Pharmaceuticals, is $0.0174 per ML (NDC 83720050216), effective Sep 30, 2026.
How has the price of DIPHENHYDRAMINE 12.5 MG/5 ML changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has risen 43.7%. It has been tracked across 73 weekly CMS publications since May 14, 2025.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 12.5 MG/5 ML?
Since May 14, 2025, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has ranged from a low of $0.0121 (Jun 18, 2025) to a high of $0.0178 (Feb 11, 2026), with a median of $0.0168 per ML.
Are there cheaper alternatives to DIPHENHYDRAMINE 12.5 MG/5 ML?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CHILD'S ALLERGY 12.5 MG/5 ML, is $0.0143 per ML — about 18% below DIPHENHYDRAMINE 12.5 MG/5 ML.
Who manufactures DIPHENHYDRAMINE 12.5 MG/5 ML?
DIPHENHYDRAMINE 12.5 MG/5 ML (NDC 83720050216) is labeled by Oncor Pharmaceuticals, and CMS classifies it as a generic product.