Clozapine
44 NDCs across 8 manufacturers|42 Generic,2 Brand
Clozapine is used to treat bipolar disorder, psychotic disorders and schizophrenia, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on Sep 26, 1989, and the first generic was approved Aug 30, 1996. FDA's Orange Book lists 32 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $108 million on Clozapine across 1.2 million claims for 69,000 beneficiaries.
Clozapine is available as 44 NDCs from 8 manufacturers (42 generic, 2 brand), with NADAC prices from $0.26 to $21.23 per EA — the most expensive product costs about 83× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
44
42G / 2B
Manufacturers
8
competing in market
Price Spread
$0.26 – $21.23
per EA
7d Activity
avg -0.7% WoW · of 44 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
Manufacturer Breakdown
8 manufacturers producing CLOZAPINE
Frequently Asked Questions
What is Clozapine used to treat?
Clozapine is used to treat bipolar disorder, psychotic disorders and schizophrenia, per the National Library of Medicine's MED-RT classification.
When did Clozapine become available as a generic?
FDA approved the first generic Clozapine (ANDA) on Aug 30, 1996. The Orange Book currently lists 32 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Clozapine?
In 2024, Medicare Part D spent $108 million on Clozapine across 1.2 million claims for 69,000 beneficiaries.
How many Clozapine products are on the market?
The Clozapine drug market contains 44 NDCs from 8 manufacturers — 42 generic and 2 brand products.
What is the price range for Clozapine?
NADAC reference prices for Clozapine range from $0.2553 to $21.2349 per EA — the most expensive product costs about 83× the cheapest.
Is generic Clozapine cheaper than brand?
The average generic NADAC for Clozapine is $4.4498 per EA, versus $11.6889 for brand-labeled products — brand versions average about 2.6× the generic price.
Which manufacturers make Clozapine?
8 manufacturers list Clozapine in NADAC. Ranked by number of NDCs, the largest are Aurobindo Pharma Limited (9), Mylan Pharmaceuticals Inc. (9), Teva Pharmaceuticals USA Inc. (8), Mylan Institutional LLC (4), Major Pharmaceuticals (4).
How has the price of Clozapine changed recently?
Over the past 7 days, 13 Clozapine NDCs rose and 25 fell, with a market-wide average change of -0.7%.