Methotrexate Sodium
5 NDCs across 4 manufacturers|5 Generic,0 Brand
Methotrexate Sodium is used to treat juvenile arthritis, rheumatoid arthritis, breast neoplasms, choriocarcinoma, crohn disease and esophageal neoplasms, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 9 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $60 million on Methotrexate Sodium across 2.4 million claims for 554,000 beneficiaries.
Methotrexate Sodium is available as 5 NDCs from 4 manufacturers (5 generic, 0 brand), with NADAC prices from $0.16 to $0.16 per EA. Every pack size and labeler in this drug market is compared side-by-side below.
Active FDA drug shortage
14 Methotrexate Sodium presentations are currently listed in FDA's drug shortage database (first posted Mar 13, 2023). Shortages can move NADAC prices in the following weeks.
Total NDCs
5
5G / 0B
Manufacturers
4
competing in market
Price Spread
$0.16 – $0.16
per EA, 4 of 5 NDCs
7d Activity
avg +0.9% WoW · of 5 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Sun Pharmaceutical Industries Inc. manufacturer profile
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Lead class
Folate Analog Metabolic Inhibitor class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
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Manufacturer Breakdown
4 manufacturers producing METHOTREXATE SODIUM
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
METHOTREXATE 250 MG/10 ML VIAL | $3.1832 per ML | +1.75% |
METHOTREXATE 2.5 MG TABLET | $0.1577 per EA | +0.74% |
METHOTREXATE 2.5 MG TABLET | $0.1577 per EA | +0.74% |
METHOTREXATE 2.5 MG TABLET | $0.1577 per EA | +0.74% |
METHOTREXATE 2.5 MG TABLET | $0.1577 per EA | +0.74% |
Frequently Asked Questions
What is Methotrexate Sodium used to treat?
Methotrexate Sodium is used to treat juvenile arthritis, rheumatoid arthritis, breast neoplasms, choriocarcinoma, crohn disease and esophageal neoplasms, per the National Library of Medicine's MED-RT classification.
When did Methotrexate Sodium become available as a generic?
FDA approved the first generic Methotrexate Sodium (ANDA) on Jan 1, 1982. The Orange Book currently lists 9 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Methotrexate Sodium?
In 2024, Medicare Part D spent $60 million on Methotrexate Sodium across 2.4 million claims for 554,000 beneficiaries.
Is Methotrexate Sodium in shortage?
Yes — FDA's drug shortage database currently lists 14 Methotrexate Sodium presentations with status "Current", first posted Mar 13, 2023.
How many Methotrexate Sodium products are on the market?
The Methotrexate Sodium drug market contains 5 NDCs from 4 manufacturers — 5 generic and 0 brand products.
What is the price range for Methotrexate Sodium?
NADAC reference prices for Methotrexate Sodium range from $0.1577 to $0.1577 per EA. 1 additional product is priced per a different unit (e.g. liquids per ML) and isn't directly comparable.
Which manufacturers make Methotrexate Sodium?
4 manufacturers list Methotrexate Sodium in NADAC. Ranked by number of NDCs, the largest are Sun Pharmaceutical Industries Inc. (2), Fresenius Kabi USA, LLC (1), Hikma Pharmaceuticals USA Inc. (1), Elite Laboratories, Inc. (1).
How has the price of Methotrexate Sodium changed recently?
Over the past 7 days, 5 Methotrexate Sodium NDCs rose and 0 fell, with a market-wide average change of +0.9%.